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    Accs 1-aminocyclopropane-1-carboxylate synthase (inactive) [ Mus musculus (house mouse) ]

    Gene ID: 329470, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Accsprovided by MGI
    Official Full Name
    1-aminocyclopropane-1-carboxylate synthase (inactive)provided by MGI
    Primary source
    MGI:MGI:1919717
    See related
    Ensembl:ENSMUSG00000040272 AllianceGenome:MGI:1919717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phacs; 2610203E10Rik
    Summary
    Predicted to enable identical protein binding activity and transaminase activity. Predicted to be involved in cellular amino acid metabolic process. Orthologous to human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 2.8), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Accs in Genome Data Viewer
    Location:
    2 E1; 2 51.62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93663812..93680343, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93833467..93849997, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene aristaless-like homeobox 4 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93662723-93662832 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase (inactive)-like Neighboring gene predicted gene, 54116 Neighboring gene STARR-seq mESC enhancer starr_05168 Neighboring gene predicted gene 1335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC48140

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    1-aminocyclopropane-1-carboxylate synthase-like protein 1
    Names
    1-aminocyclopropane-1-carboxylate synthase (non-functional)
    1-aminocyclopropane-1-carboxylate synthase homolog
    ACC synthase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290782.1 → NP_001277711.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001277711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK011867, AL732472, BC039569
      Consensus CDS
      CCDS71105.1
      UniProtKB/Swiss-Prot
      A2AIG8, Q8CHS6
      Related
      ENSMUSP00000106877.2, ENSMUST00000111246.8
      Conserved Domains (1) summary
      PLN02450
      Location:81 → 483
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    2. NM_183220.3 → NP_899043.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_899043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK011867, AL732472, BC039569
      Consensus CDS
      CCDS16457.1
      UniProtKB/Swiss-Prot
      A2AIG8
      Related
      ENSMUSP00000036268.9, ENSMUST00000041593.15
      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      93663812..93680343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239625.2 → XP_011237927.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011237927.1

      Conserved Domains (1) summary
      PLN02450
      Location:10 → 247
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    2. XM_036162322.1 → XP_036018215.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2AIG8, Q8CHS6
      Conserved Domains (1) summary
      PLN02450
      Location:81 → 483
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    3. XM_006499761.4 → XP_006499824.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499824.1

      UniProtKB/Swiss-Prot
      A2AIG8, Q8CHS6
      Conserved Domains (1) summary
      PLN02450
      Location:81 → 483
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    4. XM_006499760.4 → XP_006499823.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499823.1

      UniProtKB/Swiss-Prot
      A2AIG8, Q8CHS6
      Conserved Domains (1) summary
      PLN02450
      Location:81 → 483
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    5. XM_006499764.3 → XP_006499827.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006499827.1

      UniProtKB/Swiss-Prot
      A2AIG8
      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    6. XM_006499763.3 → XP_006499826.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006499826.1

      UniProtKB/Swiss-Prot
      A2AIG8
      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    7. XM_006499765.3 → XP_006499828.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006499828.1

      UniProtKB/Swiss-Prot
      A2AIG8
      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    8. XM_006499766.3 → XP_006499829.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006499829.1

      UniProtKB/Swiss-Prot
      A2AIG8
      Related
      ENSMUSP00000065389.5, ENSMUST00000068513.11
      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    9. XM_006499768.3 → XP_006499831.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006499831.1

      Conserved Domains (1) summary
      PLN02450
      Location:10 → 247
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    10. XM_030251803.1 → XP_030107663.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

      Conserved Domains (1) summary
      PLN02450
      Location:10 → 247
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    11. XM_030251804.1 → XP_030107664.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

      Conserved Domains (1) summary
      PLN02450
      Location:10 → 247
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    12. XM_030251802.1 → XP_030107662.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X4

      Conserved Domains (1) summary
      PLN02450
      Location:10 → 247
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    13. XM_036162323.1 → XP_036018216.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

      Conserved Domains (1) summary
      PLN02450
      Location:58 → 460
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    14. XM_011239623.1 → XP_011237925.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011237925.1

      Conserved Domains (1) summary
      cd00609
      Location:62 → 434
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

    RNA

    1. XR_374480.5 RNA Sequence

    2. XR_004940649.1 RNA Sequence

    3. XR_004940650.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AIG8.1 GenPept UniProtKB/Swiss-Prot:A2AIG8

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