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    Apol9b apolipoprotein L 9b [ Mus musculus (house mouse) ]

    Gene ID: 71898, updated on 12-May-2024

    Summary

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    Official Symbol
    Apol9bprovided by MGI
    Official Full Name
    apolipoprotein L 9bprovided by MGI
    Primary source
    MGI:MGI:1919148
    See related
    Ensembl:ENSMUSG00000068246 AllianceGenome:MGI:1919148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016F22Rik
    Summary
    Predicted to enable lipid binding activity. Orthologous to human APOL3 (apolipoprotein L3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 51.5), small intestine adult (RPKM 29.9) and 2 other tissues See more
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    Genomic context

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    See Apol9b in Genome Data Viewer
    Location:
    15 E1; 15 36.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77613248..77620582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77729047..77736382)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein L 7e Neighboring gene predicted gene, 18911 Neighboring gene predicted gene, 36329 Neighboring gene apolipoprotein L 8 Neighboring gene myosin, heavy polypeptide 9, non-muscle Neighboring gene VISTA enhancer mm1644 Neighboring gene STARR-seq mESC enhancer starr_39115 Neighboring gene STARR-seq mESC enhancer starr_39117 Neighboring gene STARR-positive B cell enhancer ABC_E8905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:77664820-77665003 Neighboring gene predicted gene, 22107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression. Kreit M, et al. J Virol, 2014 Apr. PMID 24453359, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors identified a new antiviral protein induced by interferon, ApoL9b, whose lack of expression in primary neurons likely contributes to the high sensitivity of these cells to viral infection.
      Title: Inefficient type I interferon-mediated antiviral protection of primary mouse neurons is associated with the lack of apolipoprotein l9 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L 9b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168660.1 → NP_001162131.1  apolipoprotein L 9b

      See identical proteins and their annotated locations for NP_001162131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AK009386, BF148017
      Consensus CDS
      CCDS27604.1
      UniProtKB/TrEMBL
      D3Z501, Q6PF90, Q8C7I4
      Related
      ENSMUSP00000105397.3, ENSMUST00000109775.4
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 310
      ApoL; Apolipoprotein L

    2. NM_173743.4 → NP_776104.1  apolipoprotein L 9b

      See identical proteins and their annotated locations for NP_776104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and segment for its 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK050167, BF148017
      Consensus CDS
      CCDS27604.1
      UniProtKB/TrEMBL
      D3Z501, Q6PF90, Q8C7I4
      Related
      ENSMUSP00000155314.2, ENSMUST00000230979.2
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 310
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77613248..77620582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248781.2 → XP_030104641.1  apolipoprotein L 9b isoform X1

      UniProtKB/TrEMBL
      D3Z501, Q6PF90, Q8C7I4
      Conserved Domains (1) summary
      pfam05461
      Location:1 → 310
      ApoL; Apolipoprotein L
    Nucleotide Protein Strain
    Heading Accession and Version

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