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    Ccdc103 coiled-coil domain containing 103 [ Mus musculus (house mouse) ]

    Gene ID: 73293, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ccdc103provided by MGI
    Official Full Name
    coiled-coil domain containing 103provided by MGI
    Primary source
    MGI:MGI:1920543
    See related
    Ensembl:ENSMUSG00000020930 AllianceGenome:MGI:1920543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700039D13Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in axonemal dynein complex assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to act upstream of or within cell projection organization. Predicted to be located in cytoplasm and motile cilium. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 17. Orthologous to human CCDC103 (coiled-coil domain containing 103). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 8.7), cortex adult (RPKM 0.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc103 in Genome Data Viewer
    Location:
    11 E1; 11 66.48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102772050..102776042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102881224..102885216)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HIG1 domain family, member 1B Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102742482-102742665 Neighboring gene family with sequence similarity 187, member A Neighboring gene glial fibrillary acidic protein Neighboring gene predicted gene, 34560 Neighboring gene kinesin family member 18B Neighboring gene STARR-seq mESC enhancer starr_30821

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in determination of digestive tract left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in determination of left/right symmetry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cilium movement involved in extracellular fluid movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 103

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364757.1 → NP_001351686.1  coiled-coil domain-containing protein 103 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL731670
      Conserved Domains (1) summary
      pfam13877
      Location:30 → 118
      RPAP3_C; Potential Monad-binding region of RPAP3

    2. NM_028492.3 → NP_082768.1  coiled-coil domain-containing protein 103 isoform 1

      See identical proteins and their annotated locations for NP_082768.1

      Status: VALIDATED

      Source sequence(s)
      AI836178, AK032002, AL731670
      Consensus CDS
      CCDS25506.1
      UniProtKB/Swiss-Prot
      A2AH86, Q9D9P2
      Related
      ENSMUSP00000021307.4, ENSMUST00000021307.10
      Conserved Domains (2) summary
      pfam13877
      Location:98 → 188
      RPAP3_C; Potential Monad-binding region of RPAP3
      pfam15867
      Location:7 → 74
      Dynein_attach_N; Dynein attachment factor N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102772050..102776042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9P2.1 GenPept UniProtKB/Swiss-Prot:Q9D9P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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