Itln1 intelectin 1 (galactofuranose binding) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itln1provided by MGI
Official Full Name: intelectin 1 (galactofuranose binding)provided by MGI
Primary source: MGI:MGI:1333831
See related: Ensembl:ENSMUSG00000038209 AllianceGenome:MGI:1333831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lfr; IntL; Itln; Itln2; Itln3; Itln5; Itlna
Summary: Enables oligosaccharide binding activity. Involved in response to nematode. Located in brush border membrane and membrane raft. Is expressed in several structures, including brain; eye; genitourinary system; gut; and immune system. Orthologous to several human genes including ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 1139.6), small intestine adult (RPKM 561.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.49 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171345691..171362893, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171518123..171535325, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies.
Title: The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies.
Activation of ITLN-1 attenuates oxidative stress injury via activating SIRT1/PGC1-alpha signaling in neuroblastoma cells.
Title: Activation of ITLN-1 attenuates oxidative stress injury via activating SIRT1/PGC1-α signaling in neuroblastoma cells.
Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.
Title: Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.
Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.
Title: Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.
Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.
Title: Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.
Characterization of an intelectin-1 (Itln1) knockout mouse model.
Title: Characterization of an intelectin-1 (Itln1) knockout mouse model.
Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.
Title: Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.
ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma.
Title: ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma.
Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
Title: Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels.
these studies conclude that ITLN contributes to allergen-induced Il-25, Il-33, and Tslp expression in asthma and atopic dermatitis
Title: Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in response to nematode	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intelectin-1a

Names: calcium-dependent galactosyl-specific lectin; galactofuranose-binding lectin; intelectin 2; intelectin 5; intelectin a; intestinal lactoferrin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010584.3 → NP_034714.1 intelectin-1a precursor

See identical proteins and their annotated locations for NP_034714.1

Status: VALIDATED

Source sequence(s)

AK007447, AY157364

Consensus CDS

CCDS35777.1

UniProtKB/Swiss-Prot

O88310, Q5IWS3

UniProtKB/TrEMBL

B9EK97, D9J349

Related

ENSMUSP00000043837.7, ENSMUST00000043094.13

Conserved Domains (1) summary

cl00085
Location:37 → 82

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171345691..171362893 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496676.1 → XP_006496739.1 intelectin-1a isoform X1

UniProtKB/TrEMBL

B9EK97

Conserved Domains (1) summary

cl00085
Location:37 → 82

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...