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    Ccdc61 coiled-coil domain containing 61 [ Mus musculus (house mouse) ]

    Gene ID: 232933, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ccdc61provided by MGI
    Official Full Name
    coiled-coil domain containing 61provided by MGI
    Primary source
    MGI:MGI:2685005
    See related
    Ensembl:ENSMUSG00000074358 AllianceGenome:MGI:2685005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm159; C530028I08Rik
    Summary
    Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be involved in centriole assembly and mitotic spindle assembly. Predicted to act upstream of or within cell projection organization. Predicted to be located in centriolar satellite and ciliary basal body. Predicted to be part of centriolar subdistal appendage. Predicted to be active in centrosome. Orthologous to human CCDC61 (coiled-coil domain containing 61). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.9), thymus adult (RPKM 11.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc61 in Genome Data Viewer
    Location:
    7 A3; 7 9.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18624808..18644417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18890883..18910414, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MHC I like leukocyte 2 Neighboring gene peptidoglycan recognition protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E66 Neighboring gene STARR-seq mESC enhancer starr_18181 Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene STARR-seq mESC enhancer starr_18182 Neighboring gene predicted gene, 38952 Neighboring gene nanos C2HC-type zinc finger 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein CCDC61
    Names
    VFL3 homolog
    coiled-coil domain-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033314.4 → NP_001028486.1  centrosomal protein CCDC61 isoform 1

      See identical proteins and their annotated locations for NP_001028486.1

      Status: VALIDATED

      Source sequence(s)
      AC153651
      Consensus CDS
      CCDS39791.1
      UniProtKB/Swiss-Prot
      Q3UJV1
      Related
      ENSMUSP00000096377.4, ENSMUST00000098780.10
      Conserved Domains (1) summary
      COG1196
      Location:148 → 274
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001419239.1 → NP_001406168.1  centrosomal protein CCDC61 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153651

    3. NM_001419240.1 → NP_001406169.1  centrosomal protein CCDC61 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153651
      UniProtKB/Swiss-Prot
      Q3UJV1

    4. NM_001419241.1 → NP_001406170.1  centrosomal protein CCDC61 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153651
      UniProtKB/Swiss-Prot
      Q3UJV1

    5. NM_001419242.1 → NP_001406171.1  centrosomal protein CCDC61 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153651
      UniProtKB/Swiss-Prot
      Q3UJV1

    6. NM_001419244.1 → NP_001406173.1  centrosomal protein CCDC61 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153651

    7. NM_001419245.1 → NP_001406174.1  centrosomal protein CCDC61 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153651

    8. NM_001419246.1 → NP_001406175.1  centrosomal protein CCDC61 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153651

    9. NM_001419247.1 → NP_001406176.1  centrosomal protein CCDC61 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153651

    RNA

    1. NR_185052.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153651
      Related
      ENSMUST00000135467.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18624808..18644417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152947.1 → XP_036008840.1  centrosomal protein CCDC61 isoform X3

    2. XM_006539814.5 → XP_006539877.2  centrosomal protein CCDC61 isoform X2

      See identical proteins and their annotated locations for XP_006539877.2

      UniProtKB/Swiss-Prot
      Q3UJV1
      Conserved Domains (1) summary
      COG1196
      Location:148 → 274
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_391057.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJV1.1 GenPept UniProtKB/Swiss-Prot:Q3UJV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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