Orai3 ORAI calcium release-activated calcium modulator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Orai3provided by MGI
Official Full Name: ORAI calcium release-activated calcium modulator 3provided by MGI
Primary source: MGI:MGI:3039586
See related: Ensembl:ENSMUSG00000043964 AllianceGenome:MGI:3039586
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem142c; 9930124N15
Summary: Predicted to enable store-operated calcium channel activity. Acts upstream of or within store-operated calcium entry. Located in membrane. Orthologous to human ORAI3 (ORAI calcium release-activated calcium modulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 24.5), mammary gland adult (RPKM 20.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.73 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127368987..127374322)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127769815..127775150)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells.
Title: Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells.
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
Title: ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice.
Title: Cardiac-Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice.
results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
VEGF signaling via arachidonic acid and arachidonic acid metabolism causes Orai3 to accumulate at the cell surface to mediate Ca(2+) entry and downstream endothelial cell remodeling.
Title: Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein orai-3

Names: calcium release-activated calcium channel 3; transmembrane protein 142C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.