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    Psmg4 proteasome (prosome, macropain) assembly chaperone 4 [ Mus musculus (house mouse) ]

    Gene ID: 69666, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmg4provided by MGI
    Official Full Name
    proteasome (prosome, macropain) assembly chaperone 4provided by MGI
    Primary source
    MGI:MGI:1916916
    See related
    Ensembl:ENSMUSG00000071451 AllianceGenome:MGI:1916916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAC-4; mPAC4
    Summary
    Predicted to be involved in proteasome assembly. Part of protein-containing complex. Orthologous to human PSMG4 (proteasome assembly chaperone 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 58.6), thymus adult (RPKM 52.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psmg4 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.05 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34346947..34362155)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34162964..34178172)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34137 Neighboring gene predicted gene, 36500 Neighboring gene VISTA enhancer mm1605 Neighboring gene STARR-seq mESC enhancer starr_34140 Neighboring gene STARR-seq mESC enhancer starr_34143 Neighboring gene predicted gene, 36549 Neighboring gene STARR-seq mESC enhancer starr_34144 Neighboring gene solute carrier family 22, member 23 Neighboring gene STARR-seq mESC enhancer starr_34145 Neighboring gene STARR-seq mESC enhancer starr_34148 Neighboring gene VISTA enhancer mm1307 Neighboring gene predicted gene, 53791

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 2310047M15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome assembly chaperone 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101430.2 → NP_001094900.1  proteasome assembly chaperone 4 isoform b

      See identical proteins and their annotated locations for NP_001094900.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
      Source sequence(s)
      AA124813, AC139242, BC070417
      Consensus CDS
      CCDS49230.1
      UniProtKB/Swiss-Prot
      P0C7N9
      Related
      ENSMUSP00000115881.2, ENSMUST00000147632.3
      Conserved Domains (1) summary
      pfam16093
      Location:30 → 97
      PAC4; Proteasome assembly chaperone 4

    2. NM_001110515.2 → NP_001103985.1  proteasome assembly chaperone 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an exon in the central coding region which results in a frameshift, compared to variant 2. The encoded isoform (a) is shorter and has a distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AA063946, AA124813, AC139242, AK009887
      Consensus CDS
      CCDS49231.1
      UniProtKB/TrEMBL
      D3Z016
      Related
      ENSMUSP00000120336.2, ENSMUST00000124996.8
      Conserved Domains (1) summary
      pfam16093
      Location:30 → 82
      PAC4; Proteasome assembly chaperone 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34346947..34362155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C7N9.1 GenPept UniProtKB/Swiss-Prot:P0C7N9

    Gene LinkOut

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