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    Cyth4 cytohesin 4 [ Mus musculus (house mouse) ]

    Gene ID: 72318, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cyth4provided by MGI
    Official Full Name
    cytohesin 4provided by MGI
    Primary source
    MGI:MGI:2441702
    See related
    Ensembl:ENSMUSG00000018008 AllianceGenome:MGI:2441702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pscd4; mFLJ00017; 2510004M07Rik; 5830469K17Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and intercellular bridge. Is expressed in brain. Orthologous to human CYTH4 (cytohesin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 42.0), mammary gland adult (RPKM 21.8) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cyth4 in Genome Data Viewer
    Location:
    15 E1; 15 37.59 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78481247..78506219)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78597047..78622019)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78394443-78394712 Neighboring gene Rac family small GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78402050-78402237 Neighboring gene STARR-positive B cell enhancer ABC_E11809 Neighboring gene predicted gene, 36738 Neighboring gene STARR-positive B cell enhancer ABC_E4140 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78412317-78412601 Neighboring gene STARR-positive B cell enhancer ABC_E9915 Neighboring gene STARR-positive B cell enhancer ABC_E11597 Neighboring gene STARR-positive B cell enhancer ABC_E2444 Neighboring gene STARR-positive B cell enhancer ABC_E10866 Neighboring gene predicted gene, 52186 Neighboring gene predicted gene, 52187 Neighboring gene predicted gene, 36877

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A crucial role for Arf6 in the response of commissural axons to Slit. Kinoshita-Kawada M, et al. Development, 2019 Feb 4. PMID 30674481, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00017

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytohesin-4
    Names
    PH, SEC7 and coiled-coil domain-containing protein 4
    pleckstrin homology, Sec7 and coiled/coil domains 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028195.3 → NP_082471.2  cytohesin-4

      See identical proteins and their annotated locations for NP_082471.2

      Status: VALIDATED

      Source sequence(s)
      AK152306, AK152909, BY161747
      Consensus CDS
      CCDS27620.1
      UniProtKB/Swiss-Prot
      Q80YW0
      UniProtKB/TrEMBL
      Q3U0C0, Q3U6Y6, Q3U8A6
      Related
      ENSMUSP00000042698.6, ENSMUST00000043069.6
      Conserved Domains (3) summary
      cd01252
      Location:258 → 376
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam00169
      Location:262 → 374
      PH; PH domain
      pfam01369
      Location:61 → 243
      Sec7; Sec7 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78481247..78506219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159605.1 → XP_036015498.1  cytohesin-4 isoform X4

      UniProtKB/TrEMBL
      Q05D35
      Conserved Domains (2) summary
      cd01252
      Location:235 → 353
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:38 → 220
      Sec7; Sec7 domain

    2. XM_006521446.4 → XP_006521509.1  cytohesin-4 isoform X1

      UniProtKB/TrEMBL
      Q3U6Y6, Q3U8A6
      Conserved Domains (2) summary
      cd01252
      Location:255 → 373
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:58 → 240
      Sec7; Sec7 domain

    3. XM_036159606.1 → XP_036015499.1  cytohesin-4 isoform X5

      UniProtKB/TrEMBL
      Q05D35
      Conserved Domains (2) summary
      cd01252
      Location:201 → 319
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:4 → 186
      Sec7; Sec7 domain

    4. XM_036159603.1 → XP_036015496.1  cytohesin-4 isoform X2

      Conserved Domains (2) summary
      cd01252
      Location:181 → 299
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:41 → 166
      Sec7; Sec7 domain

    5. XM_036159604.1 → XP_036015497.1  cytohesin-4 isoform X3

      Conserved Domains (2) summary
      cd01252
      Location:174 → 292
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:34 → 159
      Sec7; Sec7 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YW0.1 GenPept UniProtKB/Swiss-Prot:Q80YW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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