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    Pebp4 phosphatidylethanolamine binding protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 73523, updated on 7-May-2024

    Summary

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    Official Symbol
    Pebp4provided by MGI
    Official Full Name
    phosphatidylethanolamine binding protein 4provided by MGI
    Primary source
    MGI:MGI:1920773
    See related
    Ensembl:ENSMUSG00000022085 AllianceGenome:MGI:1920773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PEBP-4
    Summary
    Predicted to be located in extracellular region. Is expressed in bone and rib. Orthologous to human PEBP4 (phosphatidylethanolamine binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 89.7) See more
    Orthologs
    human all
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    Genomic context

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    See Pebp4 in Genome Data Viewer
    Location:
    14 D2; 14 36.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70077856..70297367)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69840407..70059918)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37064 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E10832 Neighboring gene STARR-positive B cell enhancer ABC_E7329 Neighboring gene Rho-related BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E5452 Neighboring gene STARR-seq mESC enhancer starr_37068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70261408-70261517 Neighboring gene STARR-positive B cell enhancer ABC_E9049 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_37070 Neighboring gene ribosomal protein S11 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37071 Neighboring gene predicted gene, 41198 Neighboring gene predicted gene, 33524 Neighboring gene STARR-seq mESC enhancer starr_37072 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70468715-70469016 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70469146-70469446 Neighboring gene STARR-positive B cell enhancer ABC_E8569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:70499772-70499955 Neighboring gene early growth response 3 Neighboring gene bridging integrator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylethanolamine-binding protein 4 deficiency exacerbates carbon tetrachloride-induced liver fibrosis by regulating the NF-κB signaling pathway. Luo Q, et al. Front Pharmacol, 2022. PMID 36120358, Free PMC Article
    2. Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway. Qu XQ, et al. Front Immunol, 2022. PMID 35874667, Free PMC Article
    3. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Zhang Y, et al. Int J Mol Med, 2007 Jan. PMID 17143548
    4. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions. He H, et al. Biochim Biophys Acta, 2016 Jul. PMID 27033522, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
      Title: PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
    2. Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-kappaB Pathway.
      Title: Hepatocyte-Conditional Knockout of Phosphatidylethanolamine Binding Protein 4 Aggravated LPS/D-GalN-Induced Acute Liver Injury via the TLR4/NF-κB Pathway.
    3. PEBP4 is a secreted protein and has multiple functions, including a role in Akt phosphorylation.
      Title: Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
    4. We describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mPEBP4). We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2.
      Title: Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • 1700051A02Rik, 1700081D17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylethanolamine-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028526.4 → NP_082802.1  phosphatidylethanolamine-binding protein 4 isoform b precursor

      See identical proteins and their annotated locations for NP_082802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK006750, BC048621
      UniProtKB/TrEMBL
      Q9D9L9

    2. NM_028560.4 → NP_082836.2  phosphatidylethanolamine-binding protein 4 isoform a precursor

      See identical proteins and their annotated locations for NP_082836.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC123867, AK006750, CF104379
      Consensus CDS
      CCDS27245.1
      UniProtKB/Swiss-Prot
      G3X8V3, Q9D9G2
      Related
      ENSMUSP00000022678.4, ENSMUST00000022678.5
      Conserved Domains (1) summary
      cd00866
      Location:95 → 219
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      70077856..70297367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9G2.2 GenPept UniProtKB/Swiss-Prot:Q9D9G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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