Pxk PX domain containing serine/threonine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pxkprovided by MGI
Official Full Name: PX domain containing serine/threonine kinaseprovided by MGI
Primary source: MGI:MGI:1289230
See related: Ensembl:ENSMUSG00000033885 AllianceGenome:MGI:1289230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slob; Monaka; D14Ertd813e; C230080L11Rik
Summary: Enables protein C-terminus binding activity. Involved in negative regulation of ATPase activity and negative regulation of ion transport. Acts upstream of or within modulation of chemical synaptic transmission. Located in cytoplasm and plasma membrane. Part of protein-containing complex. Is expressed in brain and spinal cord. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 18.0), placenta adult (RPKM 17.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 4.7 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (14304656..14371593, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (8098180..8165117)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MONaKA modulates brain Na,K-ATPase by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission.
Title: MONaKA, a novel modulator of the plasma membrane Na,K-ATPase.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit110 (e-PCR), detects polymorphism
- UniSTS:127212

D14Ertd813e (e-PCR), detects polymorphism
- UniSTS:167149

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of ATP-dependent activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ATP-dependent activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monoatomic ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to lysosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PX domain-containing protein kinase-like protein

Names: modulator of Na,K-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360313.1 → NP_001347242.1 PX domain-containing protein kinase-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AK150660, AK153067, AW455875

Consensus CDS

CCDS88565.1

UniProtKB/TrEMBL

A0A2C9F2B5

Related

ENSMUSP00000035265.9, ENSMUST00000036682.9

Conserved Domains (3) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

COG0515
Location:186 → 482

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
NM_001360314.1 → NP_001347243.1 PX domain-containing protein kinase-like protein short isoform

Status: VALIDATED

Source sequence(s)

AK150337, AK150660, AK153067, AW455875, CT573024

Consensus CDS

CCDS36799.1

Conserved Domains (3) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

COG0515
Location:186 → 492

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
NM_001360315.1 → NP_001347244.1 PX domain-containing protein kinase-like protein isoform 4

Status: VALIDATED

Source sequence(s)

AK150660, AK153067, AW455875, BM945330, CT573024

Conserved Domains (3) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

COG0515
Location:186 → 482

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
NM_001360316.1 → NP_001347245.1 PX domain-containing protein kinase-like protein isoform 5

Status: VALIDATED

Source sequence(s)

AK150337, AK150660, AK153067, AW455875, CT573024
NM_145458.4 → NP_663433.2 PX domain-containing protein kinase-like protein long isoform

See identical proteins and their annotated locations for NP_663433.2

Status: VALIDATED

Description

Transcript Variant: This variant (L) encodes the longest isoform.

Source sequence(s)

AK150337, AK150660, AK153067, AW455875

Consensus CDS

CCDS26810.1

UniProtKB/Swiss-Prot

Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q8BX57, Q91WB6

Related

ENSMUSP00000152987.2, ENSMUST00000225653.2

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
NM_178279.3 → NP_840063.1 PX domain-containing protein kinase-like protein short isoform

See identical proteins and their annotated locations for NP_840063.1

Status: VALIDATED

Description

Transcript Variant: This variant (S) uses an alternate splice site in the 3' coding region, compared to variant L. The resulting protein is shorter and has a distinct C-terminus, when compared to the longer isoform.

Source sequence(s)

AK150660, AK153067, AW455875, BM945330, CT573024

Consensus CDS

CCDS36799.1

UniProtKB/Swiss-Prot

Q8BX57

Related

ENSMUSP00000108309.3, ENSMUST00000112689.9

Conserved Domains (3) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

COG0515
Location:186 → 492

SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

14304656..14371593 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517982.3 → XP_006518045.1 PX domain-containing protein kinase-like protein isoform X7

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_006517977.4 → XP_006518040.1 PX domain-containing protein kinase-like protein isoform X2

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_030247724.1 → XP_030103584.1 PX domain-containing protein kinase-like protein isoform X5

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_006517980.3 → XP_006518043.1 PX domain-containing protein kinase-like protein isoform X6

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_006517975.4 → XP_006518038.1 PX domain-containing protein kinase-like protein isoform X1

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_006517978.4 → XP_006518041.1 PX domain-containing protein kinase-like protein isoform X4

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_036158542.1 → XP_036014435.1 PX domain-containing protein kinase-like protein isoform X9

Conserved Domains (3) summary

cd22062
Location:465 → 495

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_036158540.1 → XP_036014433.1 PX domain-containing protein kinase-like protein isoform X8

Conserved Domains (3) summary

cd22062
Location:466 → 496

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_036158541.1 → XP_036014434.1 PX domain-containing protein kinase-like protein isoform X8

Conserved Domains (3) summary

cd22062
Location:466 → 496

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_030247727.1 → XP_030103587.1 PX domain-containing protein kinase-like protein isoform X9

Conserved Domains (3) summary

cd22062
Location:465 → 495

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_030247728.1 → XP_030103588.1 PX domain-containing protein kinase-like protein isoform X10

Conserved Domains (2) summary

cd00180
Location:115 → 262

PKc; Catalytic domain of Protein Kinases

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_006517984.2 → XP_006518047.1 PX domain-containing protein kinase-like protein isoform X8

See identical proteins and their annotated locations for XP_006518047.1

Conserved Domains (3) summary

cd22062
Location:466 → 496

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_030247726.1 → XP_030103586.1 PX domain-containing protein kinase-like protein isoform X9

Conserved Domains (3) summary

cd22062
Location:465 → 495

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_006517985.2 → XP_006518048.1 PX domain-containing protein kinase-like protein isoform X8

See identical proteins and their annotated locations for XP_006518048.1

Conserved Domains (3) summary

cd22062
Location:466 → 496

WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins

cl02563
Location:1 → 49

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:115 → 262

PKc_like; Protein Kinases, catalytic domain
XM_017315951.2 → XP_017171440.1 PX domain-containing protein kinase-like protein isoform X6

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases
XM_017315949.2 → XP_017171438.1 PX domain-containing protein kinase-like protein isoform X3

Conserved Domains (2) summary

cd06871
Location:13 → 132

PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase

cd00180
Location:198 → 345

PKc; Catalytic domain of Protein Kinases