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    Thada thyroid adenoma associated [ Mus musculus (house mouse) ]

    Gene ID: 240174, updated on 12-May-2024

    Summary

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    Official Symbol
    Thadaprovided by MGI
    Official Full Name
    thyroid adenoma associatedprovided by MGI
    Primary source
    MGI:MGI:3039623
    See related
    Ensembl:ENSMUSG00000024251 AllianceGenome:MGI:3039623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GITA; 6530405K19; A930021O22
    Summary
    Predicted to be involved in lipid homeostasis; negative regulation of endoplasmic reticulum calcium ion concentration; and tRNA methylation. Is expressed in several structures, including cartilage; male reproductive gland or organ; nervous system; parathyroid gland; and trachea. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 2.9), thymus adult (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thada in Genome Data Viewer
    Location:
    17 E4; 17 55.02 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84497484..84773674, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84190056..84466246, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:84580066-84580358 Neighboring gene STARR-positive B cell enhancer ABC_E11651 Neighboring gene VISTA enhancer mm1108 Neighboring gene STARR-positive B cell enhancer mm9_chr17:84587213-84587514 Neighboring gene predicted gene, 41640 Neighboring gene zinc finger protein 36, C3H type-like 2 Neighboring gene predicted gene, 36279 Neighboring gene predicted gene, 24492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:84729964-84730153 Neighboring gene STARR-seq mESC enhancer starr_43435 Neighboring gene VISTA enhancer mm1109 Neighboring gene predicted gene, 24722 Neighboring gene STARR-positive B cell enhancer ABC_E7562 Neighboring gene STARR-positive B cell enhancer ABC_E5638 Neighboring gene STARR-seq mESC enhancer starr_43440 Neighboring gene predicted gene, 41642 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. Zhang Y, et al. Nat Commun, 2023 Feb 23. PMID 36823211, Free PMC Article
    2. Thada Is Dispensable for Female Fertility in Mice. Han S, et al. Front Endocrinol (Lausanne), 2022. PMID 35480478, Free PMC Article
    3. A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. Drieschner N, et al. Gene, 2007 Nov 15. PMID 17889454
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass.
      Title: THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.
    2. Thada Is Dispensable for Female Fertility in Mice.
      Title: Thada Is Dispensable for Female Fertility in Mice.
    3. A domain of Thada conserved in vertebrates becomes destroyed by chromosomal rerrangements observed in thyroid adenomas.
      Title: A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA nucleoside ribose methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (32-2'-O)-methyltransferase regulator THADA
    Names
    thyroid adenoma-associated protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426238.1 → NP_001413167.1  tRNA (32-2'-O)-methyltransferase regulator THADA

      Status: VALIDATED

      Source sequence(s)
      AC126694, AC132455, AC139329
      UniProtKB/Swiss-Prot
      A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7

    2. NM_183021.3 → NP_898842.2  tRNA (32-2'-O)-methyltransferase regulator THADA

      See identical proteins and their annotated locations for NP_898842.2

      Status: VALIDATED

      Source sequence(s)
      AC132455, AK044550, EF222207
      Consensus CDS
      CCDS50198.1
      UniProtKB/Swiss-Prot
      A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7
      Related
      ENSMUSP00000041701.9, ENSMUST00000047524.10
      Conserved Domains (1) summary
      pfam10350
      Location:953 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      84497484..84773674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524278.5 → XP_006524341.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

      Conserved Domains (1) summary
      pfam10350
      Location:600 → 886
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    2. XM_006524276.5 → XP_006524339.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

      See identical proteins and their annotated locations for XP_006524339.1

      UniProtKB/Swiss-Prot
      A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7
      Conserved Domains (1) summary
      pfam10350
      Location:953 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    3. XM_036160607.1 → XP_036016500.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

      Conserved Domains (1) summary
      pfam10350
      Location:600 → 886
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    4. XM_030249803.2 → XP_030105663.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X3

      Conserved Domains (1) summary
      pfam10350
      Location:953 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    5. XM_036160608.1 → XP_036016501.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X4

      Conserved Domains (1) summary
      pfam10350
      Location:953 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    6. XM_030249804.1 → XP_030105664.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X5

      Conserved Domains (1) summary
      pfam10350
      Location:953 → 1239
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    7. XM_030249805.1 → XP_030105665.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X6

      Conserved Domains (1) summary
      cl19897
      Location:953 → 1080
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    8. XM_036160609.1 → XP_036016502.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X7

      Conserved Domains (1) summary
      cl19897
      Location:953 → 1080
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    RNA

    1. XR_003952120.1 RNA Sequence

    2. XR_003952121.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177826.2: Suppressed sequence

      Description
      NM_177826.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8C756.1 GenPept UniProtKB/Swiss-Prot:A8C756

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