Acss2 acyl-CoA synthetase short-chain family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acss2provided by MGI
Official Full Name: acyl-CoA synthetase short-chain family member 2provided by MGI
Primary source: MGI:MGI:1890410
See related: Ensembl:ENSMUSG00000027605 AllianceGenome:MGI:1890410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ACS; ACAS; Acs1; Acas1; Acas2; aceCS; AceCS1; 1110017C11Rik
Summary: Enables acetate-CoA ligase activity and propionate-CoA ligase activity. Acts upstream of or within acetyl-CoA biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 107.5), subcutaneous fat pad adult (RPKM 101.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.26 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155359963..155404663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155518043..155562743)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-kappaB pathway.
Title: Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway.
Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
Title: Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.
Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
Title: Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis.
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
Title: ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer's disease.
Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
Title: Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.
Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
Title: Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.
Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
Title: Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
Title: Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
Title: Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.
Results suggest that ACSS2 gene is associated with human alcoholism and ethanol intake in a free-choice animal model, and even the compulsive-like behavior associated with ethanol use. Finally, slight alterations in metabolism could be responsible for the difference between ethanol non-preferring, ethanol-preferring and compulsive-like ethanol consumption.
Title: Possible involvement of ACSS2 gene in alcoholism.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in acetate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in propionate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetyl-coenzyme A synthetase, cytoplasmic

Names: acetate--CoA ligase; acetyl-CoA synthetase 1; acetyl-Coenzyme A synthetase 1 (AMP forming); acetyl-Coenzyme A synthetase 2 (ADP forming); acetyl-Coenzyme A synthetase 2 (AMP forming); acyl-activating enzyme; propionate--CoA ligase

NP_062785.2

EC 6.2.1.1

EC 6.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019811.3 → NP_062785.2 acetyl-coenzyme A synthetase, cytoplasmic

See identical proteins and their annotated locations for NP_062785.2

Status: VALIDATED

Source sequence(s)

AL844852

Consensus CDS

CCDS16950.1

UniProtKB/Swiss-Prot

Q8BK97, Q9QXG4

UniProtKB/TrEMBL

Q8C141, Q8C1A8

Related

ENSMUSP00000029135.9, ENSMUST00000029135.15

Conserved Domains (1) summary

cd05966
Location:45 → 685

ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)