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    P2ry10b purinergic receptor P2Y, G-protein coupled 10B [ Mus musculus (house mouse) ]

    Gene ID: 213438, updated on 11-Apr-2024

    Summary

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    Official Symbol
    P2ry10bprovided by MGI
    Official Full Name
    purinergic receptor P2Y, G-protein coupled 10Bprovided by MGI
    Primary source
    MGI:MGI:2441814
    See related
    Ensembl:ENSMUSG00000054293 AllianceGenome:MGI:2441814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P2ry10; A630033H20Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 2.9), spleen adult (RPKM 2.2) and 15 other tissues See more
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    Genomic context

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    Location:
    X D; X 47.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106192533..106217268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107148927..107173661)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 4 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene purinergic receptor P2Y, G-protein coupled 10 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene prohibitin pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:104413022-104413322 Neighboring gene STARR-positive B cell enhancer ABC_E7704 Neighboring gene G protein-coupled receptor 174 Neighboring gene alpha-enolase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. Inoue A, et al. Nat Methods, 2012 Oct. PMID 22983457
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    purinergic receptor P2Y G-protein coupled 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122595.1 → NP_001116067.1  purinergic receptor P2Y G-protein coupled 10-like

      See identical proteins and their annotated locations for NP_001116067.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL928594
      Consensus CDS
      CCDS41099.1
      UniProtKB/TrEMBL
      Q8BY68
      Related
      ENSMUSP00000136348.2, ENSMUST00000180182.2
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001122596.1 → NP_001116068.1  purinergic receptor P2Y G-protein coupled 10-like

      See identical proteins and their annotated locations for NP_001116068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL928594
      Consensus CDS
      CCDS41099.1
      UniProtKB/TrEMBL
      Q8BY68
      Related
      ENSMUSP00000133122.2, ENSMUST00000167673.2
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_175442.4 → NP_780651.1  purinergic receptor P2Y G-protein coupled 10-like

      See identical proteins and their annotated locations for NP_780651.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL928594
      Consensus CDS
      CCDS41099.1
      UniProtKB/TrEMBL
      Q8BY68
      Related
      ENSMUSP00000065588.3, ENSMUST00000067249.3
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      106192533..106217268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161902.1 → XP_036017795.1  purinergic receptor P2Y G-protein coupled 10-like isoform X1

      UniProtKB/TrEMBL
      Q8BY68
      Conserved Domains (2) summary
      cd14964
      Location:23 → 50
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:23 → 304
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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