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    Zfp462 zinc finger protein 462 [ Mus musculus (house mouse) ]

    Gene ID: 242466, updated on 12-May-2024

    Summary

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    Official Symbol
    Zfp462provided by MGI
    Official Full Name
    zinc finger protein 462provided by MGI
    Primary source
    MGI:MGI:107690
    See related
    Ensembl:ENSMUSG00000060206 AllianceGenome:MGI:107690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gt4-2; Zfpip; Znf462; 6030417H05; 9430078C22Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within chromatin organization; negative regulation of DNA binding activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; jaw; and limb primordium. Used to study generalized anxiety disorder. Orthologous to human ZNF462 (zinc finger protein 462). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.4), whole brain E14.5 (RPKM 11.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp462 in Genome Data Viewer
    Location:
    4 B2; 4 29.5 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (54942038..55083563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (54944491..55083563)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10263 Neighboring gene STARR-seq mESC enhancer starr_10264 Neighboring gene STARR-seq mESC enhancer starr_10265 Neighboring gene predicted gene, 34133 Neighboring gene TPX2, microtubule-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_10266 Neighboring gene STARR-seq mESC enhancer starr_10268 Neighboring gene STARR-seq mESC enhancer starr_10269 Neighboring gene predicted gene 8364 Neighboring gene STARR-seq mESC enhancer starr_10270 Neighboring gene STARR-seq mESC enhancer starr_10271 Neighboring gene STARR-seq mESC enhancer starr_10272 Neighboring gene STARR-seq mESC enhancer starr_10273 Neighboring gene STARR-seq mESC enhancer starr_10275 Neighboring gene predicted gene, 42289 Neighboring gene STARR-seq mESC enhancer starr_10277 Neighboring gene predicted gene 12514 Neighboring gene splicing factor, arginine/serine-rich 7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. Yelagandula R, et al. Nat Cell Biol, 2023 Jan. PMID 36604593, Free PMC Article
    2. ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate. Massé J, et al. Exp Cell Res, 2011 Aug 1. PMID 21570965
    3. Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA. Laurent A, et al. Mech Dev, 2007 May. PMID 17353115
    4. A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Skarnes WC, et al. Genes Dev, 1992 Jun. PMID 1592261
    5. Graded expression of Zfp462 in the embryonic mouse cerebral cortex. Chang YS, et al. Gene Expr Patterns, 2007 Feb. PMID 17207666

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
      Title: miR-377-3p Regulates Hippocampal Neurogenesis via the Zfp462-Pbx1 Pathway and Mediates Anxiety-Like Behaviors in Prenatal Hypoxic Offspring.
    2. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
      Title: ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers.
    3. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
      Title: Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
    4. The ZFPIP/Zfp462 is a key chromatin factor involved in maintaining P19 pluripotency and in the early mechanisms of neural differentiation but that it is dispensable in differentiated P19 cells.
      Title: ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate.
    5. An instrumental role of ZFPIP/Zfp462 in maintaining the chromatin structure of pluripotent cells.
      Title: Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.
    6. Study shows that Zfp462 is expressed in the developing central nervous system, branchial arches, otic vesicles, sensory ganglia, somites and limbs.
      Title: Graded expression of Zfp462 in the embryonic mouse cerebral cortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transposon induced (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 462
    Names
    gene trap insertion site 4-2
    zinc finger PBX1-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172867.4 → NP_766455.2  zinc finger protein 462

      See identical proteins and their annotated locations for NP_766455.2

      Status: VALIDATED

      Source sequence(s)
      AL772186, AL844140
      Consensus CDS
      CCDS38764.1
      UniProtKB/Swiss-Prot
      A2SW42, B1AWL2
      Related
      ENSMUSP00000095677.4, ENSMUST00000098070.10
      Conserved Domains (2) summary
      sd00017
      Location:2016 → 2036
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2014 → 2038
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      54942038..55083563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253536.2 → XP_030109396.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_006537917.5 → XP_006537980.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006537980.1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_036164123.1 → XP_036020016.1  zinc finger protein 462 isoform X11

      Conserved Domains (2) summary
      sd00017
      Location:1155 → 1175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1153 → 1177
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_036164113.1 → XP_036020006.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_030253535.2 → XP_030109395.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_006537915.3 → XP_006537978.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006537978.1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    7. XM_030253545.2 → XP_030109405.1  zinc finger protein 462 isoform X9

      Conserved Domains (2) summary
      sd00017
      Location:1216 → 1236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1214 → 1238
      zf-H2C2_5; C2H2-type zinc-finger domain

    8. XM_036164124.1 → XP_036020017.1  zinc finger protein 462 isoform X11

      Conserved Domains (2) summary
      sd00017
      Location:1155 → 1175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1153 → 1177
      zf-H2C2_5; C2H2-type zinc-finger domain

    9. XM_030253546.2 → XP_030109406.1  zinc finger protein 462 isoform X11

      Conserved Domains (2) summary
      sd00017
      Location:1155 → 1175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1153 → 1177
      zf-H2C2_5; C2H2-type zinc-finger domain

    10. XM_030253534.2 → XP_030109394.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    11. XM_006537916.3 → XP_006537979.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006537979.1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    12. XM_030253537.2 → XP_030109397.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    13. XM_006537919.4 → XP_006537982.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006537982.1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    14. XM_036164112.1 → XP_036020005.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    15. XM_006537918.5 → XP_006537981.1  zinc finger protein 462 isoform X1

      See identical proteins and their annotated locations for XP_006537981.1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    16. XM_036164111.1 → XP_036020004.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2077 → 2097
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    17. XM_036164118.1 → XP_036020011.1  zinc finger protein 462 isoform X6

      Conserved Domains (2) summary
      sd00017
      Location:2043 → 2063
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    18. XM_036164115.1 → XP_036020008.1  zinc finger protein 462 isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:2040 → 2060
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2038 → 2062
      zf-H2C2_5; C2H2-type zinc-finger domain

    19. XM_036164114.1 → XP_036020007.1  zinc finger protein 462 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:2076 → 2096
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2074 → 2098
      zf-H2C2_5; C2H2-type zinc-finger domain

    20. XM_036164116.1 → XP_036020009.1  zinc finger protein 462 isoform X4

      Conserved Domains (2) summary
      sd00017
      Location:2039 → 2059
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2037 → 2061
      zf-H2C2_5; C2H2-type zinc-finger domain

    21. XM_036164117.1 → XP_036020010.1  zinc finger protein 462 isoform X5

      UniProtKB/Swiss-Prot
      A2SW42, B1AWL2
      Conserved Domains (2) summary
      sd00017
      Location:2016 → 2036
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2014 → 2038
      zf-H2C2_5; C2H2-type zinc-finger domain

    22. XM_036164119.1 → XP_036020012.1  zinc finger protein 462 isoform X7

      Conserved Domains (2) summary
      sd00017
      Location:2016 → 2036
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2014 → 2038
      zf-H2C2_5; C2H2-type zinc-finger domain

    23. XM_036164121.1 → XP_036020014.1  zinc finger protein 462 isoform X9

      Conserved Domains (2) summary
      sd00017
      Location:1216 → 1236
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1214 → 1238
      zf-H2C2_5; C2H2-type zinc-finger domain

    24. XM_036164122.1 → XP_036020015.1  zinc finger protein 462 isoform X10

      Conserved Domains (2) summary
      sd00017
      Location:1215 → 1235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1213 → 1237
      zf-H2C2_5; C2H2-type zinc-finger domain

    25. XM_036164120.1 → XP_036020013.1  zinc finger protein 462 isoform X8

      Conserved Domains (2) summary
      sd00017
      Location:2043 → 2063
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2075 → 2099
      zf-H2C2_5; C2H2-type zinc-finger domain

    RNA

    1. XR_004941892.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AWL2.1 GenPept UniProtKB/Swiss-Prot:B1AWL2

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