A4gnt alpha-1,4-N-acetylglucosaminyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: A4gntprovided by MGI
Official Full Name: alpha-1,4-N-acetylglucosaminyltransferaseprovided by MGI
Primary source: MGI:MGI:2143261
See related: Ensembl:ENSMUSG00000037953 AllianceGenome:MGI:2143261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm798; Alpha4gnt
Summary: This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]
Expression: Biased expression in stomach adult (RPKM 13.0), duodenum adult (RPKM 7.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.91 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (99473233..99504420)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (99591179..99622367)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A4gnt(-/-) mice show complete lack of alphaGlcNAc expression in gastric gland mucin
Title: Essential role of gastric gland mucin in preventing gastric cancer in mice.
This publication contains functional information for the human homolog of mouse A4gnt.
Title: Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.
This publication contains functional information for the human homolog of mouse A4gnt.
Title: Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

BM383234 (e-PCR)
- UniSTS:260784

NoName (e-PCR)
- UniSTS:488641

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylglucosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein O-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-1,4-N-acetylglucosaminyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077424.2 → NP_001070892.1 alpha-1,4-N-acetylglucosaminyltransferase

See identical proteins and their annotated locations for NP_001070892.1

Status: REVIEWED

Source sequence(s)

AC157949, AK136425

Consensus CDS

CCDS40740.1

UniProtKB/Swiss-Prot

Q14BT6

Related

ENSMUSP00000045629.8, ENSMUST00000042553.8

Conserved Domains (2) summary

pfam04488
Location:65 → 183

Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif

pfam04572
Location:202 → 324

Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

99473233..99504420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511246.5 → XP_006511309.1 alpha-1,4-N-acetylglucosaminyltransferase isoform X2

See identical proteins and their annotated locations for XP_006511309.1

UniProtKB/Swiss-Prot

Q14BT6

Conserved Domains (2) summary

pfam04488
Location:65 → 183

Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif

pfam04572
Location:202 → 324

Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
XM_006511244.5 → XP_006511307.3 alpha-1,4-N-acetylglucosaminyltransferase isoform X1

Conserved Domains (2) summary

pfam04488
Location:130 → 248

Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif

pfam04572
Location:267 → 389

Gb3_synth; Alpha 1,4-glycosyltransferase conserved region