Htr2a 5-hydroxytryptamine (serotonin) receptor 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr2aprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 2Aprovided by MGI
Primary source: MGI:MGI:109521
See related: Ensembl:ENSMUSG00000034997 AllianceGenome:MGI:109521
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Htr2; Htr-2; 5-HT-2; 5-HT-2A; E030013E04
Summary: Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphorylation; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 3.5), cortex adult (RPKM 2.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 39.37 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (74878314..74944299)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (74640874..74706859)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.
Title: Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.
CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.
Title: CX3CR1 mediates motor dysfunction in mice through 5-HTR2a.
5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice.
Title: 5-HT1A receptor in the central amygdala and 5-HT2A receptor in the basolateral amygdala are involved in social hierarchy in male mice.
Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
Title: Glucocorticoid receptor dysregulation underlies 5-HT(2A)R-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes.
Title: Serotonin Receptor 5-HT(2A) Regulates TrkB Receptor Function in Heteroreceptor Complexes.
Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.
Title: Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3.
5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction.
Title: 5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction.
PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
Title: PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.
HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.
Title: HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.
Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation.
Title: Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT(2A) receptor activation.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr2a (e-PCR), detects polymorphism
- UniSTS:265493

Htr2a (e-PCR), detects polymorphism
- UniSTS:143421

Htr2a (e-PCR), detects polymorphism
- UniSTS:143422

HTR2A-2 (e-PCR)
- UniSTS:31941

HTR2A-112F (e-PCR)
- UniSTS:31941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heat generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensitization	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cell body fiber	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with neurofilament	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2A

Names: 5-HT2A receptor; 5-hydroxytryptamine 2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172812.3 → NP_766400.1 5-hydroxytryptamine receptor 2A

See identical proteins and their annotated locations for NP_766400.1

Status: VALIDATED

Source sequence(s)

AK053140

Consensus CDS

CCDS27275.1

UniProtKB/Swiss-Prot

P35363

UniProtKB/TrEMBL

Q543D4

Related

ENSMUSP00000047774.4, ENSMUST00000036653.5

Conserved Domains (2) summary

pfam00001
Location:91 → 380

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:89 → 207

7tm_4; Olfactory receptor