Gmip Gem-interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gmipprovided by MGI
Official Full Name: Gem-interacting proteinprovided by MGI
Primary source: MGI:MGI:1926066
See related: Ensembl:ENSMUSG00000036246 AllianceGenome:MGI:1926066
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5031419I10Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and negative regulation of GTPase activity. Predicted to be active in plasma membrane. Is expressed in brain; hippocampus; ovary; testis; and thyroid gland. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 38.0), thymus adult (RPKM 25.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 33.88 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70260912..70274520)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (69808298..69821870)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gmip serves as a brake for the RhoA-mediated movement of neuronal somata, highlighting the significance of speed control in the well-organized neuronal migration and the maintenance of neuronal circuits in the postnatal brain.
Title: Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GEM-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198101.1 → NP_932769.1 GEM-interacting protein

See identical proteins and their annotated locations for NP_932769.1

Status: PROVISIONAL

Source sequence(s)

BC057037

Consensus CDS

CCDS22350.1

UniProtKB/Swiss-Prot

Q6P9S3, Q6PGG2

Related

ENSMUSP00000045676.9, ENSMUST00000036074.15

Conserved Domains (4) summary

TIGR02473
Location:87 → 217

flagell_FliJ; flagellar export protein FliJ

smart00109
Location:491 → 536

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cl02570
Location:548 → 751

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

cl12013
Location:112 → 312

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70260912..70274520

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509799.5 → XP_006509862.1 GEM-interacting protein isoform X6

Conserved Domains (3) summary

smart00109
Location:595 → 640

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cl02570
Location:652 → 732

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:216 → 416

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030243857.2 → XP_030099717.2 GEM-interacting protein isoform X4

Related

ENSMUSP00000116542.2, ENSMUST00000123453.2

Conserved Domains (3) summary

cd04408
Location:652 → 855

RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...

cd20816
Location:595 → 644

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl12013
Location:216 → 416

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006509797.5 → XP_006509860.2 GEM-interacting protein isoform X1

Conserved Domains (3) summary

smart00109
Location:491 → 536

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cl02570
Location:548 → 751

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:112 → 312

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006509798.5 → XP_006509861.2 GEM-interacting protein isoform X3

Conserved Domains (3) summary

smart00109
Location:491 → 536

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cd04408
Location:548 → 751

RhoGAP_GMIP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase ...

cl12013
Location:112 → 312

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036154385.1 → XP_036010278.1 GEM-interacting protein isoform X5

Conserved Domains (3) summary

cd20816
Location:358 → 407

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:415 → 618

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:58 → 179

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036154386.1 → XP_036010279.1 GEM-interacting protein isoform X5

Conserved Domains (3) summary

cd20816
Location:358 → 407

C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family

cl02570
Location:415 → 618

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:58 → 179

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030243856.2 → XP_030099716.1 GEM-interacting protein isoform X2

Conserved Domains (3) summary

smart00109
Location:503 → 548

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cl02570
Location:560 → 763

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:124 → 324

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature