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    Sorcs3 sortilin-related VPS10 domain containing receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 66673, updated on 12-May-2024

    Summary

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    Official Symbol
    Sorcs3provided by MGI
    Official Full Name
    sortilin-related VPS10 domain containing receptor 3provided by MGI
    Primary source
    MGI:MGI:1913923
    See related
    Ensembl:ENSMUSG00000063434 AllianceGenome:MGI:1913923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330404A12Rik
    Summary
    Acts upstream of or within learning; memory; and regulation of long-term synaptic depression. Located in postsynaptic density. Is integral component of postsynaptic density membrane. Is active in glutamatergic synapse. Is expressed in several structures, including brain; cochlea; genitourinary system; retina; and trigeminal ganglion. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 4.4), frontal lobe adult (RPKM 4.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sorcs3 in Genome Data Viewer
    Location:
    19 D1; 19 41.32 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (48194464..48793944)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (48206025..48805505)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47994118-47994301 Neighboring gene STARR-positive B cell enhancer mm9_chr19:48011969-48012270 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein Neighboring gene cilia and flagella associated protein 58 Neighboring gene STARR-seq mESC enhancer starr_46376 Neighboring gene STARR-seq mESC enhancer starr_46378 Neighboring gene STARR-seq mESC enhancer starr_46379 Neighboring gene STARR-seq mESC enhancer starr_46381 Neighboring gene STARR-seq mESC enhancer starr_46382 Neighboring gene STARR-seq mESC enhancer starr_46383 Neighboring gene STARR-seq mESC enhancer starr_46384 Neighboring gene STARR-seq mESC enhancer starr_46385 Neighboring gene STARR-seq mESC enhancer starr_46386 Neighboring gene STARR-seq mESC enhancer starr_46387 Neighboring gene STARR-seq mESC enhancer starr_46388 Neighboring gene STARR-seq mESC enhancer starr_46389 Neighboring gene STARR-seq mESC enhancer starr_46390 Neighboring gene STARR-seq mESC enhancer starr_46391 Neighboring gene STARR-seq mESC enhancer starr_46392 Neighboring gene STARR-seq mESC enhancer starr_46393 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus. Christiansen GB, et al. Hippocampus, 2017 Mar. PMID 27935149
    2. SORCS1 and SORCS3 control energy balance and orexigenic peptide production. Subkhangulova A, et al. EMBO Rep, 2018 Apr. PMID 29440124, Free PMC Article
    3. Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice. Hermey G, et al. Biol Chem, 2019 Aug 27. PMID 31095505
    4. Spatiotemporal expression analysis of the growth factor receptor SorCS3. Oetjen S, et al. J Comp Neurol, 2014 Oct 15. PMID 24715575
    5. The three sorCS genes are differentially expressed and regulated by synaptic activity. Hermey G, et al. J Neurochem, 2004 Mar. PMID 15009648

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex
      Title: Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.
    2. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
      Title: SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
    3. SorCS3 serves as a key regulator of synaptic transmission and plasticity. Results show that glutamate receptor functions are controlled by SorCS3 to secure correct functioning of excitatory synapses. The receptor plays a more central role in CA1 compared to the dentate gyrus, correlating well with the expression pattern. Reduced function of SorCS3 results in impaired synaptic mechanisms in the hippocampus.
      Title: The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.
    4. Study demonstrates that SorCS3 expression is restricted to the developing and adult nervous system
      Title: Spatiotemporal expression analysis of the growth factor receptor SorCS3.
    5. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
      Title: Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
    6. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
      Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VPS10 domain-containing receptor SorCS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025696.3 → NP_079972.1  VPS10 domain-containing receptor SorCS3 precursor

      See identical proteins and their annotated locations for NP_079972.1

      Status: VALIDATED

      Source sequence(s)
      AC122363, AC126046, AC127434, AC141870
      Consensus CDS
      CCDS38020.1
      UniProtKB/Swiss-Prot
      Q8VI51, Q9CTR4
      UniProtKB/TrEMBL
      Q1HL22
      Related
      ENSMUSP00000077919.6, ENSMUST00000078880.6
      Conserved Domains (3) summary
      smart00602
      Location:216 → 814
      VPS10; VPS10 domain
      pfam00801
      Location:828 → 901
      PKD; PKD domain
      pfam15901
      Location:658 → 814
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      48194464..48793944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI51.1 GenPept UniProtKB/Swiss-Prot:Q8VI51

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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