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    Arhgap5 Rho GTPase activating protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299012, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Arhgap5provided by RGD
    Official Full Name
    Rho GTPase activating protein 5provided by RGD
    Primary source
    RGD:1308507
    See related
    Ensembl:ENSRNOG00000004696 AllianceGenome:RGD:1308507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00098
    Summary
    Predicted to enable SH2 domain binding activity. Involved in mammary gland development. Predicted to be active in cytosol and endoplasmic reticulum. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 346.5), Kidney (RPKM 278.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap5 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75711199..75774636)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69975904..70039299)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (73345129..73408304)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479384 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis. Wang S, et al. Metab Brain Dis, 2023 Apr. PMID 36790698
    2. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. McHenry PR, et al. Breast Cancer Res, 2010. PMID 20860838, Free PMC Article
    3. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Heckman-Stoddard BM, et al. Breast Cancer Res, 2009. PMID 19703301, Free PMC Article
    4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Chakravarty G, et al. Cell Growth Differ, 2000 Jul. PMID 10939588
    5. MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. Fang Y, et al. Oncotarget, 2015 May 30. PMID 25961434, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis.
      Title: Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammary gland development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell size IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399400.1 → NP_001386329.1  rho GTPase-activating protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6HBI5
      Conserved Domains (5) summary
      smart00441
      Location:428 → 481
      FF; Contains two conserved F residues
      cd04373
      Location:1261 → 1445
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260 → 338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22220
      Location:592 → 762
      pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
      cl38936
      Location:31 → 246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      75711199..75774636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111971.2 → XP_038967899.1  rho GTPase-activating protein 5 isoform X1

      UniProtKB/TrEMBL
      A6HBI5, E9PTJ5, Q6TUE6
      Conserved Domains (5) summary
      smart00441
      Location:428 → 481
      FF; Contains two conserved F residues
      cd04373
      Location:1261 → 1445
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260 → 338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22220
      Location:592 → 762
      pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
      cl38936
      Location:31 → 246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_017594084.3 → XP_017449573.1  rho GTPase-activating protein 5 isoform X1

      UniProtKB/TrEMBL
      A6HBI5, E9PTJ5, Q6TUE6
      Conserved Domains (5) summary
      smart00441
      Location:428 → 481
      FF; Contains two conserved F residues
      cd04373
      Location:1261 → 1445
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260 → 338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22220
      Location:592 → 762
      pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
      cl38936
      Location:31 → 246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_063261673.1 → XP_063117743.1  rho GTPase-activating protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7N9

    4. XM_039111972.2 → XP_038967900.1  rho GTPase-activating protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7N9, E9PTJ5, Q6TUE6
      Related
      ENSRNOP00000074284.2
      Conserved Domains (5) summary
      smart00441
      Location:428 → 481
      FF; Contains two conserved F residues
      cd04373
      Location:1260 → 1444
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260 → 338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cd22220
      Location:592 → 762
      pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
      cl38936
      Location:31 → 246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047869.1: Suppressed sequence

      Description
      NM_001047869.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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