Rnase1 ribonuclease, RNase A family, 1 (pancreatic) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnase1provided by MGI
Official Full Name: ribonuclease, RNase A family, 1 (pancreatic)provided by MGI
Primary source: MGI:MGI:97919
See related: Ensembl:ENSMUSG00000035896 AllianceGenome:MGI:97919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rib1; Rib-1
Summary: Predicted to enable ribonuclease activity. Acts upstream of or within response to bacterium. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; integumental system; limb segment; and reproductive system. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 1501.1), spleen adult (RPKM 698.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 26.4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51382459..51384224, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51145002..51146767, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that one of the physiological functions of RNase 1 is to degrade extracellular RNA in blood plasma. Loss of this function facilitates FXII and FXI activation, which could have effects on inflammation and blood coagulation.
Title: Phenotype of ribonuclease 1 deficiency in mice.
Vascular RNase1 and RNase5 are mainly produced by vascular endothelial cells and can serve, depending on the vascular bed, different functions in vascular homeostasis and endothelial cell responses.
Title: Expression and localisation of vascular ribonucleases in endothelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

Rnase1 (e-PCR), detects polymorphism
- UniSTS:463468

X60103 (e-PCR)
- UniSTS:125816

Rib1 (e-PCR), detects polymorphism
- UniSTS:144350

AI574248 (e-PCR)
- UniSTS:163551

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease A activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease pancreatic

Names: RNase 1; RNase A; ribonuclease 1, pancreatic

NP_035401.2

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.