Adrm1 adhesion regulating molecule 1 26S proteasome ubiquitin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adrm1provided by MGI
Official Full Name: adhesion regulating molecule 1 26S proteasome ubiquitin receptorprovided by MGI
Primary source: MGI:MGI:1929289
See related: Ensembl:ENSMUSG00000039041 AllianceGenome:MGI:1929289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arm1; ARM-1; Gp110; Rpn13; 1110063P18Rik; 2510006J17Rik
Summary: Predicted to enable several functions, including endopeptidase activator activity; proteasome binding activity; and ubiquitin binding activity. Involved in several processes, including germ cell development; gonad development; and positive regulation of growth hormone receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of proteasome regulatory particle, lid subcomplex. Is expressed in genitourinary system; sensory organ; and skeleton. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 108.3), duodenum adult (RPKM 65.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.69 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179813381..179818076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180171588..180176283)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors show that Shigella flexneri invasion plasmid antigen H (IpaH) 4.5, a member of the E3 ubiquitin ligase effector family, targets the proteasome regulatory particle non-ATPase 13 (RPN13) and induces its degradation via the ubiquitin-proteasome system (UPS).
Title: Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation.
ADRM1-dependent ubiquitin proteasome system (UPS) may be a general mechanism to guard cells from mutant Htt toxicity
Title: The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
studies suggest that HAP40-mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction.
Title: Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects.
Data show that either Rpn13 knock down or RA190 treatment reduced the capacity of myeloid-derived-suppressor cells (MDSCs) to suppress T cell proliferation in vitro.
Title: RPN13/ADRM1 inhibitor reverses immunosuppression by myeloid-derived suppressor cells.
the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation.
Title: Binding of SGTA to Rpn13 selectively modulates protein quality control.
this study showed that Rpn13 plays a redundant role with Rpn10 in recognition and degradation of ubiquitinated proteins in mouse livers.
Title: Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
show that Rpn13 is involved in inducible nitric oxide synthase degradation and is required for iNOS interaction with the deubiquitination protein UCH37.
Title: Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).
crystallography and NMR data to describe the ubiquitin-binding mechanism of Rpn13
Title: Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome
Title: Proteasome subunit Rpn13 is a novel ubiquitin receptor.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125816 (e-PCR)
- UniSTS:162562

RH124758 (e-PCR)
- UniSTS:161580

AI853660 (e-PCR)
- UniSTS:178792

AU043535 (e-PCR)
- UniSTS:159148

RH124685 (e-PCR)
- UniSTS:161507

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle-stimulating hormone signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth hormone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thymus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasomal ubiquitin receptor ADRM1

Names: 110 kDa cell membrane glycoprotein; adhesion-regulating molecule 1; glycoprotein 110; rpn13 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019822.3 → NP_062796.2 proteasomal ubiquitin receptor ADRM1

See identical proteins and their annotated locations for NP_062796.2

Status: PROVISIONAL

Source sequence(s)

AL663027

Consensus CDS

CCDS17171.1

UniProtKB/Swiss-Prot

Q3UKZ8, Q8BPH8, Q922A7, Q9JKV1

UniProtKB/TrEMBL

A0A0A6YVU8

Related

ENSMUSP00000050076.5, ENSMUST00000061437.5

Conserved Domains (2) summary

cd13314
Location:24 → 128

PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

pfam16550
Location:274 → 381

RPN13_C; UCH-binding domain