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    washc2c WASH complex subunit 2C [ Danio rerio (zebrafish) ]

    Gene ID: 567272, updated on 27-Mar-2024

    Summary

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    Official Symbol
    washc2cprovided by ZNC
    Official Full Name
    WASH complex subunit 2Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060825-87
    See related
    Ensembl:ENSDARG00000062532 AllianceGenome:ZFIN:ZDB-GENE-060825-87
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam21c; wu:fb78c06; zgc:153646
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Predicted to be involved in protein localization to endosome and retrograde transport, endosome to Golgi. Predicted to be part of WASH complex. Predicted to be active in early endosome. Orthologous to several human genes including WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See washc2c in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (18073208..18122343, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (17942140..17991353, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene membrane-associated ring finger (C3HC4) 8 Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene arachidonate 5-lipoxygenase a Neighboring gene solute carrier family 25 member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153646

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retromer complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein localization to endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of WASH complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WASH complex subunit FAM21; WASH complex subunit 2; WASH complex subunit 2C
    Names
    family with sequence similarity 21, member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      18073208..18122343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307266.3 → XP_009305541.1  WASH complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_009305541.1

      UniProtKB/TrEMBL
      A0A8M2B2V0
      Conserved Domains (1) summary
      pfam15255
      Location:1001 → 1127
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    2. XM_021480773.1 → XP_021336448.1  WASH complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QA68
      Conserved Domains (2) summary
      pfam15255
      Location:975 → 1109
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 321
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    3. XM_017358961.2 → XP_017214450.1  WASH complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z9C4

    4. XM_003199716.5 → XP_003199764.1  WASH complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M1RJ04
      Conserved Domains (1) summary
      pfam15255
      Location:1000 → 1126
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    5. XM_005156705.4 → XP_005156762.1  WASH complex subunit 2C isoform X3

      UniProtKB/TrEMBL
      A0A8M2B314
      Related
      ENSDARP00000119265.1, ENSDART00000148125.3
      Conserved Domains (1) summary
      pfam15255
      Location:993 → 1109
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    6. XM_005156704.4 → XP_005156761.1  WASH complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_005156761.1

      UniProtKB/TrEMBL
      A0A8M2B2V0
      Conserved Domains (1) summary
      pfam15255
      Location:1001 → 1127
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394875.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      36951..87134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472699.1 → XP_021328374.1  WASH complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PU42
      Conserved Domains (2) summary
      pfam15255
      Location:975 → 1109
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 321
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    2. XM_021472697.1 → XP_021328372.1  WASH complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PBF7
      Conserved Domains (2) summary
      pfam15255
      Location:996 → 1130
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 317
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    3. XM_021472700.1 → XP_021328375.1  WASH complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q511
      Conserved Domains (2) summary
      pfam15255
      Location:965 → 1099
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 317
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    4. XM_021472698.1 → XP_021328373.1  WASH complex subunit 2C isoform X3

      UniProtKB/TrEMBL
      A0A8M9PMY0
      Conserved Domains (2) summary
      pfam15255
      Location:972 → 1113
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 317
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    5. XM_021472694.1 → XP_021328369.1  WASH complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU38
      Conserved Domains (2) summary
      pfam15255
      Location:997 → 1131
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 317
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    6. XM_021472696.1 → XP_021328371.1  WASH complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PU38
      Conserved Domains (2) summary
      pfam15255
      Location:997 → 1131
      CAP-ZIP_m; WASH complex subunit CAP-Z interacting, central region
      cl26761
      Location:63 → 317
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001045855.1: Suppressed sequence

      Description
      NM_001045855.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: FAM21A (GeneID:387680).
    Nucleotide Protein Strain
    Heading Accession and Version

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