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    dapk3 death-associated protein kinase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 562194, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dapk3provided by ZNC
    Official Full Name
    death-associated protein kinase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3026
    See related
    Ensembl:ENSDARG00000074447 AllianceGenome:ZFIN:ZDB-GENE-030131-3026
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc25b08; si:dkey-57k2.5
    Summary
    Enables protein kinase activity. Predicted to be involved in intracellular signal transduction and positive regulation of apoptotic process. Predicted to act upstream of or within protein phosphorylation. Located in cytoplasm and nucleus. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See dapk3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37467942..37478491, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37486326..37496059, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, iota Neighboring gene si:dkey-127k13.1 Neighboring gene polyhomeotic homolog 3 (Drosophila) Neighboring gene signal peptide peptidase-like 2 Neighboring gene rho/rac guanine nucleotide exchange factor (GEF) 18a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the zebrafish homolog of zipper interacting protein kinase. Carr BW, et al. Int J Mol Sci, 2014 Jun 30. PMID 24983477, Free PMC Article
    2. ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene. Shoval Y, et al. PLoS Genet, 2007 Oct. PMID 17953487, Free PMC Article
    3. Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis. Castets M, et al. Dev Cell, 2009 Apr. PMID 19386270
    4. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Blaser H, et al. Dev Cell, 2006 Nov. PMID 17084355
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death-associated protein kinase 3
    Names
    zipk
    XP_690685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37467942..37478491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685593.8 → XP_690685.1  death-associated protein kinase 3

      UniProtKB/TrEMBL
      A0A8N7UT33, E9QHI3
      Related
      ENSDARP00000120152.1, ENSDART00000146103.2
      Conserved Domains (2) summary
      smart00220
      Location:13 → 275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14105
      Location:7 → 275
      STKc_DAPK; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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