coa6 cytochrome c oxidase assembly factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: coa6provided by ZNC
Official Full Name: cytochrome c oxidase assembly factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-152
See related: Ensembl:ENSDARG00000092677 AllianceGenome:ZFIN:ZDB-GENE-070705-152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-258f14.5
Summary: Acts upstream of or within heart development. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 4. Orthologous to human COA6 (cytochrome c oxidase assembly factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (4832144..4834622, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (4823574..4826052, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in respiratory chain complex IV assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within respiratory chain complex IV assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c oxidase assembly factor 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327831.1 → NP_001314760.1 cytochrome c oxidase assembly factor 6 homolog

Status: VALIDATED

Source sequence(s)

BX546489, EH477105, EH544899

UniProtKB/TrEMBL

A0A8M1P9E4, B8A5J2

Related

ENSDARP00000116578.1, ENSDART00000141539.2

Conserved Domains (1) summary

pfam02297
Location:3 → 66

COX6B; Cytochrome oxidase c subunit VIb