U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    plekha5 pleckstrin homology domain containing, family A member 5 [ Danio rerio (zebrafish) ]

    Gene ID: 567300, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    plekha5provided by ZNC
    Official Full Name
    pleckstrin homology domain containing, family A member 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041210-25
    See related
    Ensembl:ENSDARG00000045870 AllianceGenome:ZFIN:ZDB-GENE-041210-25
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb16e08; si:ch211-239h19.1
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be active in cytosol. Orthologous to human PLEKHA5 (pleckstrin homology domain containing A5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See plekha5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (2948062..3145380, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (3017952..3215271, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A, cGMP-inhibited Neighboring gene AE binding protein 2 Neighboring gene intestine-specific homeobox-like Neighboring gene protein bicaudal D homolog 1-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus. Liu Y, et al. Mol Cell Endocrinol, 2013 Jul 15. PMID 23623870
    2. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-5-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    pleckstrin homology domain-containing family A member 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327786.1 → NP_001314715.1  pleckstrin homology domain-containing family A member 5

      Status: VALIDATED

      Source sequence(s)
      BX088564, BX914207, LO018342
      UniProtKB/TrEMBL
      A0A8M1P9B3, F1R8A2
      Related
      ENSDARP00000099969.4, ENSDART00000112210.4
      Conserved Domains (3) summary
      cd13248
      Location:164 → 267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 266
      PH; PH domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      2948062..3145380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164474.4 → XP_005164531.1  pleckstrin homology domain-containing family A member 5 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BBV2
      Conserved Domains (3) summary
      cd13248
      Location:164 → 267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 266
      PH; PH domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    2. XM_021475091.1 → XP_021330766.1  pleckstrin homology domain-containing family A member 5 isoform X18

      UniProtKB/TrEMBL
      A0A8M9Q602
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:720 → 911
      DUF3084; Protein of unknown function (DUF3084)

    3. XM_021475090.1 → XP_021330765.1  pleckstrin homology domain-containing family A member 5 isoform X16

      UniProtKB/TrEMBL
      A0A8M9QBD7
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:720 → 911
      DUF3084; Protein of unknown function (DUF3084)

    4. XM_021475089.1 → XP_021330764.1  pleckstrin homology domain-containing family A member 5 isoform X15

      UniProtKB/TrEMBL
      A0A8M9Q0N0
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:720 → 912
      DUF3084; Protein of unknown function (DUF3084)

    5. XM_021475086.1 → XP_021330761.1  pleckstrin homology domain-containing family A member 5 isoform X11

      UniProtKB/TrEMBL
      A0A8M9Q5Z9
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:721 → 929
      DUF3084; Protein of unknown function (DUF3084)

    6. XM_021475085.1 → XP_021330760.1  pleckstrin homology domain-containing family A member 5 isoform X10

      UniProtKB/TrEMBL
      A0A8M9QBD3
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:721 → 930
      DUF3084; Protein of unknown function (DUF3084)

    7. XM_021475082.1 → XP_021330757.1  pleckstrin homology domain-containing family A member 5 isoform X7

      UniProtKB/TrEMBL
      A0A8M9PHE0
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:721 → 957
      DUF3084; Protein of unknown function (DUF3084)

    8. XM_021475088.1 → XP_021330763.1  pleckstrin homology domain-containing family A member 5 isoform X14

      UniProtKB/TrEMBL
      A0A8M9PUM1
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl25732
      Location:731 → 955
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_021475081.1 → XP_021330756.1  pleckstrin homology domain-containing family A member 5 isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q5Z6
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl25732
      Location:731 → 955
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_021475080.1 → XP_021330755.1  pleckstrin homology domain-containing family A member 5 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QBC6
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl26472
      Location:721 → 970
      DUF3084; Protein of unknown function (DUF3084)

    11. XM_021475078.1 → XP_021330753.1  pleckstrin homology domain-containing family A member 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PUL1
      Conserved Domains (2) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    12. XM_021475083.1 → XP_021330758.1  pleckstrin homology domain-containing family A member 5 isoform X8

      UniProtKB/TrEMBL
      A0A8M9PUL6
      Conserved Domains (2) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    13. XM_021475077.1 → XP_021330752.1  pleckstrin homology domain-containing family A member 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PHD6
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl25732
      Location:822 → 983
      SMC_N; RecF/RecN/SMC N terminal domain

    14. XM_021475087.1 → XP_021330762.1  pleckstrin homology domain-containing family A member 5 isoform X12

      UniProtKB/TrEMBL
      A0A8M9PHE4
      Conserved Domains (1) summary
      cd13248
      Location:107 → 210
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    15. XM_005164479.4 → XP_005164536.1  pleckstrin homology domain-containing family A member 5 isoform X17

      UniProtKB/TrEMBL
      A0A8M2BBQ9
      Conserved Domains (2) summary
      cd13248
      Location:43 → 146
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:49 → 145
      PH; PH domain

    16. XM_021475084.1 → XP_021330759.1  pleckstrin homology domain-containing family A member 5 isoform X9

      UniProtKB/TrEMBL
      A0A8M9Q0M6
      Conserved Domains (1) summary
      cd13248
      Location:112 → 215
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    17. XM_009300003.2 → XP_009298278.1  pleckstrin homology domain-containing family A member 5 isoform X13

      UniProtKB/TrEMBL
      A0A8M3B8Q5
      Conserved Domains (2) summary
      cd13248
      Location:99 → 202
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:105 → 201
      PH; PH domain

    18. XM_009300011.3 → XP_009298286.1  pleckstrin homology domain-containing family A member 5 isoform X21

      UniProtKB/TrEMBL
      A0A8M3B1H1
      Conserved Domains (3) summary
      cd13248
      Location:164 → 267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 266
      PH; PH domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    19. XM_009300010.3 → XP_009298285.1  pleckstrin homology domain-containing family A member 5 isoform X19

      UniProtKB/TrEMBL
      A0A8M3ARD7
      Conserved Domains (3) summary
      cd13248
      Location:164 → 267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 266
      PH; PH domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    20. XM_009299999.3 → XP_009298274.1  pleckstrin homology domain-containing family A member 5 isoform X20

      UniProtKB/TrEMBL
      A0A8M3AR53
      Conserved Domains (3) summary
      cd13248
      Location:164 → 267
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 266
      PH; PH domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    21. XM_021475093.1 → XP_021330768.1  pleckstrin homology domain-containing family A member 5 isoform X22

      UniProtKB/TrEMBL
      A0A8M9PUM6
      Conserved Domains (2) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain

    22. XM_021475079.1 → XP_021330754.1  pleckstrin homology domain-containing family A member 5 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q0M2
      Conserved Domains (3) summary
      cd13248
      Location:177 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:13 → 42
      WW; WW domain
      cl25732
      Location:822 → 983
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. XR_002458106.1 RNA Sequence

    2. XR_002458107.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools