slc25a38b solute carrier family 25 member 38b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc25a38bprovided by ZNC
Official Full Name: solute carrier family 25 member 38bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110214-1
See related: Ensembl:ENSDARG00000074533 AllianceGenome:ZFIN:ZDB-GENE-110214-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable glycine transmembrane transporter activity. Involved in erythrocyte differentiation. Acts upstream of or within hemoglobin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in blood; blood island; and posterior cardinal vein. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (7721290..7735042, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (7564121..7577861, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine import into mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine import into mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in glycine import into mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemoglobin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hemoglobin metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial glycine transporter B; solute carrier family 25 member 38-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202458.1 → NP_001189387.1 mitochondrial glycine transporter B

See identical proteins and their annotated locations for NP_001189387.1

Status: VALIDATED

Source sequence(s)

CR925711

UniProtKB/Swiss-Prot

I3IT61, P0CAT2

Related

ENSDARP00000126117.1, ENSDART00000151545.3

Conserved Domains (2) summary

PTZ00168
Location:10 → 263

PTZ00168; mitochondrial carrier protein; Provisional

pfam00153
Location:8 → 99

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

7721290..7735042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476924.1 → XP_021332599.1 solute carrier family 25 member 38-B isoform X1

UniProtKB/TrEMBL

A0A8M9Q680

Conserved Domains (1) summary

pfam00153
Location:20 → 111

Mito_carr; Mitochondrial carrier protein