plcd1b phospholipase C, delta 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plcd1bprovided by ZNC
Official Full Name: phospholipase C, delta 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9435
See related: Ensembl:ENSDARG00000034080 AllianceGenome:ZFIN:ZDB-GENE-030131-9435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Plcd1; fj78d10; zgc:55868; wu:fj78d10
Summary: Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol-mediated signaling. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Is expressed in lens; neuromast; and solid lens vesicle. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (21387898..21438492, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21729836..21780430, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi38e10.x1 (e-PCR)
- UniSTS:197428

z44809 (e-PCR), detects polymorphism
- UniSTS:238788

fj78d10.x1 (e-PCR)
- UniSTS:199895

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b; phospholipase C, delta 1b

Names: DrPLC-delta 1B

NP_956362.1

EC 3.1.4.11

XP_005163413.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200068.1 → NP_956362.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b

See identical proteins and their annotated locations for NP_956362.1

Status: PROVISIONAL

Source sequence(s)

BC051157

UniProtKB/TrEMBL

Q7ZU40

Related

ENSDARP00000046097.6, ENSDART00000046098.9

Conserved Domains (7) summary

cd00275
Location:620 → 745

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08629
Location:291 → 587

PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1

PLN02228
Location:209 → 741

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:21 → 136

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:25 → 127

PH; PH domain

pfam09279
Location:210 → 291

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:156 → 205

EF-hand_10; EF hand

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

21387898..21438492 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163356.4 → XP_005163413.1 phospholipase C, delta 1b isoform X1

UniProtKB/TrEMBL

A0A8M2BAJ8

Conserved Domains (7) summary

cd00275
Location:643 → 768

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08629
Location:314 → 610

PI-PLCc_delta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta1

PLN02228
Location:232 → 764

PLN02228; Phosphoinositide phospholipase C

cd13363
Location:44 → 159

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:48 → 150

PH; PH domain

pfam09279
Location:233 → 314

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam14788
Location:179 → 228

EF-hand_10; EF hand