Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2a4provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily a, polypeptide 4provided by MGI
Primary source: MGI:MGI:88596
See related: Ensembl:ENSMUSG00000074254 AllianceGenome:MGI:88596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp15a1; D7Ucla4
Summary: Predicted to enable enzyme binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within response to stilbenoid. Predicted to be located in cytoplasmic microtubule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to several human genes including CYP2A13 (cytochrome P450 family 2 subfamily A member 13) and CYP2A6 (cytochrome P450 family 2 subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 202.7) and kidney adult (RPKM 62.7) See more
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Genomic context

Location:: 7 A3; 7 14.39 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (26006617..26014513)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (26307192..26315088)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that the Cyp2a(4/5)bgs-null mice developed a preference for nicotine in a conditioned place preference test
Title: Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

Submit: New GeneRIF Correction

General gene information

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Markers

AI893559 (e-PCR)
- UniSTS:179536

D17973 (e-PCR)
- UniSTS:124754

J03549 (e-PCR)
- UniSTS:159611

Cyp2a4 (e-PCR), detects polymorphism
- UniSTS:462989

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables coumarin 7-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in coumarin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2A4

Names: CYPIIA4; cytochrome P450, 2a4; cytochrome P450-15-alpha; cytochrome P450-IIA3.1; testosterone 15-alpha-hydroxylase; testosterone 15alpha-hydroxylase

NP_034127.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.