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    Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 108097, updated on 12-May-2024

    Summary

    Official Symbol
    Prkab2provided by MGI
    Official Full Name
    protein kinase, AMP-activated, beta 2 non-catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1336185
    See related
    Ensembl:ENSMUSG00000038205 AllianceGenome:MGI:1336185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730553K21Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to contribute to AMP-activated protein kinase activity. Involved in positive regulation of cold-induced thermogenesis. Predicted to be located in apical plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex and nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; gallbladder; genitourinary system; and nervous system. Orthologous to human PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 27.2), heart adult (RPKM 10.1) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prkab2 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97565527..97581128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97658211..97673812)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene flavin containing monooxygenase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene STARR-positive B cell enhancer ABC_E6086 Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242 Neighboring gene phosphodiesterase 4D interacting protein (myomegalin) Neighboring gene microRNA 7225

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP-activated protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nutrient levels NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit beta-2
    Names
    AMPK subunit beta-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182997.2NP_892042.2  5'-AMP-activated protein kinase subunit beta-2

      See identical proteins and their annotated locations for NP_892042.2

      Status: PROVISIONAL

      Source sequence(s)
      BC060228
      Consensus CDS
      CCDS17657.1
      UniProtKB/Swiss-Prot
      Q6PAM0
      Related
      ENSMUSP00000036410.7, ENSMUST00000045743.13
      Conserved Domains (2) summary
      smart01010
      Location:182271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:76158
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      97565527..97581128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252348.1XP_030108208.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

      Conserved Domains (2) summary
      smart01010
      Location:138227
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:32114
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    2. XM_011239982.4XP_011238284.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_011238284.1

      UniProtKB/Swiss-Prot
      Q6PAM0
      Conserved Domains (2) summary
      smart01010
      Location:182271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:76158
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    3. XM_006500840.3XP_006500903.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006500903.1

      UniProtKB/Swiss-Prot
      Q6PAM0
      Conserved Domains (2) summary
      smart01010
      Location:182271
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:76158
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    4. XM_006500841.3XP_006500904.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

      Conserved Domains (2) summary
      smart01010
      Location:138227
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:32114
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase