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    Ppp2r3d protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta [ Mus musculus (house mouse) ]

    Gene ID: 19054, updated on 22-May-2024

    Summary

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    Official Symbol
    Ppp2r3dprovided by MGI
    Official Full Name
    protein phosphatase 2 (formerly 2A), regulatory subunit B'', deltaprovided by MGI
    Primary source
    MGI:MGI:1335093
    See related
    Ensembl:ENSMUSG00000093803 AllianceGenome:MGI:1335093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PR59; Ppp2r3; Ppp2r3a; PP2A PR59; PP2A B''-PR59
    Summary
    Enables calcium-dependent protein serine/threonine phosphatase activity; chromatin binding activity; and protein phosphatase regulator activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and protein dephosphorylation. Part of protein phosphatase type 2A complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human PPP2R3B (protein phosphatase 2 regulatory subunit B''beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Ppp2r3d in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (124195310..124204755)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (124474346..124476862, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family, pyrin domain containing 4G Neighboring gene predicted gene, 20783 Neighboring gene RIKEN cDNA 4930526I15 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Voorhoeve PM, et al. Oncogene, 1999 Jan 14. PMID 9927208
    2. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Zwaenepoel K, et al. BMC Genomics, 2008 Aug 20. PMID 18715506, Free PMC Article
    3. Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution. Nishi A, et al. J Biol Chem, 2017 Jan 27. PMID 27998980, Free PMC Article
    4. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Yan Z, et al. Mol Cell Biol, 2000 Feb. PMID 10629059, Free PMC Article
    5. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta
    Names
    protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
    protein phosphatase 2, regulatory subunit (59 kDa)
    protein phosphatase 2, regulatory subunit B, alpha
    protein phosphatase 2A, 59 kDa regulatory subunit B
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    NP_001156887.1
    NP_001392087.1
    NP_035284.2
    XP_036010587.1
    XP_036010589.1
    XP_036010590.1
    XP_036010591.1
    XP_036010592.1
    XP_036010593.1
    XP_036010594.1
    XP_036010595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163415.2 → NP_001156887.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 1

      See identical proteins and their annotated locations for NP_001156887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      LXEJ02012085
      UniProtKB/TrEMBL
      A0A7N9VRA1, Q8K1A4
      Related
      ENSMUSP00000159447.4, ENSMUST00000239563.3
      Conserved Domains (1) summary
      pfam13499
      Location:343 → 394
      EF-hand_7; EF-hand domain pair

    2. NM_001405158.1 → NP_001392087.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

      Status: VALIDATED

      Source sequence(s)
      LXEJ02012085

    3. NM_011154.2 → NP_035284.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform 2

      See identical proteins and their annotated locations for NP_035284.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK054122, AK143212, BC096544, CB723063, CF735315
      UniProtKB/Swiss-Prot
      Q9Z176
      Related
      ENSMUSP00000140113.3, ENSMUST00000188509.3
      Conserved Domains (1) summary
      cl41751
      Location:71 → 426
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    RNA

    1. NR_028110.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK054122, BC096544
      Related
      ENSMUST00000217354.4

    2. NR_102716.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' exon and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK054122, AK143212, BC096544
      Related
      ENSMUST00000216394.3

    3. NR_175917.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      LXEJ02012085

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      124195310..124204755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154702.1 → XP_036010595.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

      Conserved Domains (1) summary
      cl41751
      Location:2 → 198
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    2. XM_036154694.1 → XP_036010587.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X1

      UniProtKB/TrEMBL
      A0A7N9VRA1
      Conserved Domains (1) summary
      cl41751
      Location:105 → 460
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    3. XM_036154700.1 → XP_036010593.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X7

      Conserved Domains (1) summary
      cl41751
      Location:1 → 319
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    4. XM_036154699.1 → XP_036010592.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X6

      Conserved Domains (1) summary
      cl41751
      Location:1 → 319
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    5. XM_036154696.1 → XP_036010589.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X3

      UniProtKB/Swiss-Prot
      Q9Z176
      Conserved Domains (1) summary
      cl41751
      Location:71 → 426
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    6. XM_036154701.1 → XP_036010594.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X8

      Conserved Domains (1) summary
      cl41751
      Location:2 → 198
      PPP2R3; serine/threonine protein phosphatase 2A regulatory subunit B"

    7. XM_036154698.1 → XP_036010591.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X5

      Conserved Domains (1) summary
      cd21504
      Location:157 → 395
      PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins

    8. XM_036154697.1 → XP_036010590.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta isoform X4

      Conserved Domains (1) summary
      cd21504
      Location:157 → 395
      PPP2R3A_B-like; serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins

    RNA

    1. XR_004935343.1 RNA Sequence

    2. XR_004935344.1 RNA Sequence

    3. XR_004935345.1 RNA Sequence

    4. XR_004935347.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039134.1: Suppressed sequence

      Description
      NM_001039134.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z176.1 GenPept UniProtKB/Swiss-Prot:Q9Z176

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