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    Adcy4 adenylate cyclase 4 [ Mus musculus (house mouse) ]

    Gene ID: 104110, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adcy4provided by MGI
    Official Full Name
    adenylate cyclase 4provided by MGI
    Primary source
    MGI:MGI:99674
    See related
    Ensembl:ENSMUSG00000022220 AllianceGenome:MGI:99674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4004
    Summary
    Predicted to enable G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activity; and protein kinase C binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 35.4), subcutaneous fat pad adult (RPKM 10.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adcy4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56006513..56021552, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55769056..55784095, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor 1 Neighboring gene predicted gene, 32092 Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr14:56441298-56441599 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure. Chen K, et al. Transl Res, 2022 Jun. PMID 35114419, Free PMC Article
    2. Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling. Kittikulsuth W, et al. Physiol Rep, 2014. PMID 24760529, Free PMC Article
    3. Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4. Al-Hakim A, et al. Mol Cell Endocrinol, 2004 Feb 12. PMID 15062554
    4. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Gao BN, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946437, Free PMC Article
    5. Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells. Rui X, et al. Endocrinology, 2008 Jul. PMID 18388192, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
      Title: In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
    2. SF1 and SP1 contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site.
      Title: Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells.
    3. Adcy4 deficiency is a hallmark of the forskolin-resistant phenotype of the adrenocortical tumor mutants studied and Adcy4 is an important target of forskolin action in the Y1 adrenal cell line.
      Title: Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4004

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cAMP biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase type 4
    Names
    ATP pyrophosphate-lyase 4
    adenylate cyclase type IV
    adenylyl cyclase 4
    NP_001348533.1
    NP_536683.1
    XP_006518387.1
    XP_006518388.1
    XP_006518389.1
    XP_036014230.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361604.1 → NP_001348533.1  adenylate cyclase type 4

      Status: VALIDATED

      Source sequence(s)
      AC098877, AK141767, BY346402
      Consensus CDS
      CCDS27130.1
      UniProtKB/Swiss-Prot
      Q91WF3
      UniProtKB/TrEMBL
      Q3UR61
      Related
      ENSMUSP00000130530.2, ENSMUST00000170223.9
      Conserved Domains (3) summary
      pfam00211
      Location:866 → 1065
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:115 → 246
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:479 → 580
      DUF1053; Domain of Unknown Function (DUF1053)

    2. NM_080435.2 → NP_536683.1  adenylate cyclase type 4

      See identical proteins and their annotated locations for NP_536683.1

      Status: VALIDATED

      Source sequence(s)
      AC098877, AK141767, AK161880, BY346402
      Consensus CDS
      CCDS27130.1
      UniProtKB/Swiss-Prot
      Q91WF3
      UniProtKB/TrEMBL
      Q3UR61
      Related
      ENSMUSP00000002398.8, ENSMUST00000002398.9
      Conserved Domains (3) summary
      pfam00211
      Location:866 → 1065
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:115 → 246
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:479 → 580
      DUF1053; Domain of Unknown Function (DUF1053)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56006513..56021552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518324.1 → XP_006518387.1  adenylate cyclase type 4 isoform X1

      See identical proteins and their annotated locations for XP_006518387.1

      UniProtKB/Swiss-Prot
      Q91WF3
      UniProtKB/TrEMBL
      Q3UR61
      Conserved Domains (3) summary
      pfam00211
      Location:866 → 1065
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:115 → 246
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:479 → 580
      DUF1053; Domain of Unknown Function (DUF1053)

    2. XM_036158337.1 → XP_036014230.1  adenylate cyclase type 4 isoform X4

      Conserved Domains (3) summary
      pfam00211
      Location:525 → 724
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:138 → 239
      DUF1053; Domain of Unknown Function (DUF1053)
      cl11967
      Location:15 → 77
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    3. XM_006518326.3 → XP_006518389.1  adenylate cyclase type 4 isoform X3

      Conserved Domains (3) summary
      pfam00211
      Location:552 → 751
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam06327
      Location:165 → 266
      DUF1053; Domain of Unknown Function (DUF1053)
      cl11967
      Location:2 → 104
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    4. XM_006518325.3 → XP_006518388.1  adenylate cyclase type 4 isoform X2

      UniProtKB/TrEMBL
      Q3TSQ4, Q3UR61
      Conserved Domains (4) summary
      pfam00211
      Location:264 → 418
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam16214
      Location:115 → 246
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      pfam06327
      Location:479 → 580
      DUF1053; Domain of Unknown Function (DUF1053)
      cl11967
      Location:866 → 939
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WF3.1 GenPept UniProtKB/Swiss-Prot:Q91WF3

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