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    Zfp655 zinc finger protein 655 [ Mus musculus (house mouse) ]

    Gene ID: 72611, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp655provided by MGI
    Official Full Name
    zinc finger protein 655provided by MGI
    Primary source
    MGI:MGI:1919861
    See related
    Ensembl:ENSMUSG00000007812 AllianceGenome:MGI:1919861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700038I16Rik; 9030409O18Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ZNF655 (zinc finger protein 655). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.2), bladder adult (RPKM 6.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp655 in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145168503..145184116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145231595..145247306)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 14 Neighboring gene STARR-positive B cell enhancer ABC_E1316 Neighboring gene STARR-positive B cell enhancer ABC_E533 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene predicted gene 9710 Neighboring gene STARR-positive B cell enhancer ABC_E6398 Neighboring gene zinc finger and SCAN domain containing 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Kajimura S, et al. Nature, 2009 Aug 27. PMID 19641492, Free PMC Article
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 655

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083958.2 → NP_001077427.1  zinc finger protein 655 isoform b

      See identical proteins and their annotated locations for NP_001077427.1

      Status: VALIDATED

      Source sequence(s)
      AK161949
      Consensus CDS
      CCDS51698.1
      UniProtKB/TrEMBL
      Q6P8W7
      Related
      ENSMUSP00000143198.2, ENSMUST00000200039.5
      Conserved Domains (1) summary
      pfam01352
      Location:77 → 117
      KRAB; KRAB box

    2. NM_001347533.2 → NP_001334462.1  zinc finger protein 655 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Consensus CDS
      CCDS84998.1
      UniProtKB/TrEMBL
      A0A0G2JEM1
      Related
      ENSMUSP00000142825.2, ENSMUST00000199003.5

    3. NM_001363449.1 → NP_001350378.1  zinc finger protein 655 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC127411, AK018500, AK161949
      Consensus CDS
      CCDS90015.1
      UniProtKB/TrEMBL
      A0A0G2JE56
      Related
      ENSMUSP00000142639.2, ENSMUST00000196069.5

    4. NM_001363451.1 → NP_001350380.1  zinc finger protein 655 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Conserved Domains (3) summary
      COG5048
      Location:206 → 274
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:303 → 323
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001363452.1 → NP_001350381.1  zinc finger protein 655 isoform f

      Status: VALIDATED

      Source sequence(s)
      AK161949, BG078636, BY717878
      UniProtKB/TrEMBL
      F7AFH2
      Related
      ENSMUSP00000082803.9, ENSMUST00000085661.9

    6. NM_028298.4 → NP_082574.1  zinc finger protein 655 isoform a

      See identical proteins and their annotated locations for NP_082574.1

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Consensus CDS
      CCDS19861.1
      UniProtKB/TrEMBL
      Q5DTG8, Q9CZP3
      Related
      ENSMUSP00000128969.2, ENSMUST00000167316.8
      Conserved Domains (3) summary
      COG5048
      Location:400 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:363 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:334 → 356
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145168503..145184116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165532.1 → XP_036021425.1  zinc finger protein 655 isoform X1

      UniProtKB/TrEMBL
      Q5DTG8, Q9CZP3
      Conserved Domains (3) summary
      COG5048
      Location:400 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:363 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:334 → 356
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_017321114.3 → XP_017176603.1  zinc finger protein 655 isoform X1

      UniProtKB/TrEMBL
      Q5DTG8, Q9CZP3
      Conserved Domains (3) summary
      COG5048
      Location:400 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:363 → 383
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:334 → 356
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_030254832.1 → XP_030110692.1  zinc finger protein 655 isoform X2

      UniProtKB/TrEMBL
      Q6P8W7
      Conserved Domains (1) summary
      pfam01352
      Location:77 → 117
      KRAB; KRAB box
    Nucleotide Protein Strain
    Heading Accession and Version

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