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    Zfp821 zinc finger protein 821 [ Mus musculus (house mouse) ]

    Gene ID: 75871, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp821provided by MGI
    Official Full Name
    zinc finger protein 821provided by MGI
    Primary source
    MGI:MGI:1923121
    See related
    Ensembl:ENSMUSG00000031728 AllianceGenome:MGI:1923121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf821; 4930566A11Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and retina nuclear layer. Orthologous to human ZNF821 (zinc finger protein 821). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 11.3), testis adult (RPKM 11.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp821 in Genome Data Viewer
    Location:
    8 D3; 8 57.21 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110421884..110451564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109695252..109724932)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene dihydroorotate dehydrogenase Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene increased sodium tolerance 1 homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene predicted gene, 53453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112261750-112261859 Neighboring gene ataxin 1-like Neighboring gene STARR-seq mESC enhancer starr_22658 Neighboring gene predicted gene, 51550 Neighboring gene La ribonucleoprotein domain family, member 1B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells. Tan X, et al. Stem Cell Res, 2013 Nov. PMID 23954693
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 821

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167946.2 → NP_001161418.1  zinc finger protein 821 isoform a

      See identical proteins and their annotated locations for NP_001161418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-8 all encode the same isoform (a).
      Source sequence(s)
      AC132138, AK136168, BC059844
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Related
      ENSMUSP00000034163.9, ENSMUST00000034163.9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    2. NM_001286391.1 → NP_001273320.1  zinc finger protein 821 isoform b

      See identical proteins and their annotated locations for NP_001273320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 9-11 all encode the same isoform (b).
      Source sequence(s)
      AC132138, AK165387, BC059844
      Consensus CDS
      CCDS85609.1
      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001286393.1 → NP_001273322.1  zinc finger protein 821 isoform b

      See identical proteins and their annotated locations for NP_001273322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 3, 4 and 9-11 all encode the same isoform (b).
      Source sequence(s)
      AC132138, AK136168, BC059844
      Consensus CDS
      CCDS85609.1
      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Related
      ENSMUSP00000148334.2, ENSMUST00000212964.2
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001363380.1 → NP_001350309.1  zinc finger protein 821 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, and 6-8, encodes isoform a.
      Source sequence(s)
      AC132138, BC059014, CN714981, CN721180
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    5. NM_001363381.1 → NP_001350310.1  zinc finger protein 821 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 5, 7, and 8, encodes isoform a.
      Source sequence(s)
      AC132138, BC059014
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    6. NM_001363382.1 → NP_001350311.1  zinc finger protein 821 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 5, 6, and 8, encodes isoform a.
      Source sequence(s)
      AC132138, BC059014, CF173118
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    7. NM_001363383.1 → NP_001350312.1  zinc finger protein 821 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 5, 6, and 7, encodes isoform a
      Source sequence(s)
      AC132138
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    8. NM_001363384.1 → NP_001350313.1  zinc finger protein 821 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 3, 4, 10, and 11, encodes isoform b.
      Source sequence(s)
      AC132138, BC059014, CN721180
      Consensus CDS
      CCDS85609.1
      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001363385.1 → NP_001350314.1  zinc finger protein 821 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC132138
      Consensus CDS
      CCDS85609.1
      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001363386.1 → NP_001350315.1  zinc finger protein 821 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 3, 4, 9, and 10, encodes isoform b.
      Source sequence(s)
      AC132138, BC059014, BM950913
      Consensus CDS
      CCDS85609.1
      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_029468.3 → NP_083744.2  zinc finger protein 821 isoform a

      See identical proteins and their annotated locations for NP_083744.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-8 all encode the same isoform (a).
      Source sequence(s)
      BC059014, BC059844, BY240329
      Consensus CDS
      CCDS40473.1
      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Related
      ENSMUSP00000148348.2, ENSMUST00000212000.2
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110421884..110451564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243833.1 → XP_030099693.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036154363.1 → XP_036010256.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036154360.1 → XP_036010253.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_011248534.4 → XP_011246836.1  zinc finger protein 821 isoform X1

      See identical proteins and their annotated locations for XP_011246836.1

      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    5. XM_036154358.1 → XP_036010251.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036154362.1 → XP_036010255.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036154359.1 → XP_036010252.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_030243831.1 → XP_030099691.1  zinc finger protein 821 isoform X1

      UniProtKB/Swiss-Prot
      E9Q0F1, Q3UWR1, Q6PD05
      UniProtKB/TrEMBL
      A0A1D5RLA9
      Conserved Domains (4) summary
      sd00017
      Location:121 → 141
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:151 → 173
      zf-C2H2; Zinc finger, C2H2 type
      pfam07946
      Location:290 → 355
      DUF1682; Protein of unknown function (DUF1682)
      cl27170
      Location:243 → 383
      DUF460; Protein of unknown function (DUF460)

    9. XM_036154357.1 → XP_036010250.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_030243832.2 → XP_030099692.1  zinc finger protein 821 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLE5, Q8R572
      Conserved Domains (2) summary
      TIGR01642
      Location:125 → 237
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      sd00017
      Location:2 → 22
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PD05.2 GenPept UniProtKB/Swiss-Prot:Q6PD05

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