Acin1 apoptotic chromatin condensation inducer 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acin1provided by MGI
Official Full Name: apoptotic chromatin condensation inducer 1provided by MGI
Primary source: MGI:MGI:1891824
See related: Ensembl:ENSMUSG00000022185 AllianceGenome:MGI:1891824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acn; Acinus; acinusL; acinusS; mKIAA0670; 2610036I19Rik; 2610510L13Rik
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of apoptotic process. Predicted to act upstream of or within apoptotic process. Located in nucleolus. Is expressed in several structures, including central nervous system; connective tissue; early conceptus; olfactory epithelium; and retina. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 53.8), CNS E14 (RPKM 33.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.87 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54879618..54924422, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54642161..54686965, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gp70 enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus and MCM2 resulting in the activation of DNA-PK to phosphorylate P53.
Title: A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acin1 (e-PCR), detects polymorphism
- UniSTS:479062

RH126909 (e-PCR)
- UniSTS:209028

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic chromosome condensation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ASAP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ASAP complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apoptotic chromatin condensation inducer in the nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085472.2 → NP_001078941.2 apoptotic chromatin condensation inducer in the nucleus isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

BC052755, BC094217, BY287113

Consensus CDS

CCDS49492.1

UniProtKB/TrEMBL

B8JJ92

Related

ENSMUSP00000122003.4, ENSMUST00000148754.10

Conserved Domains (2) summary

cd12432
Location:253 → 339

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:407 → 482

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_001085473.2 → NP_001078942.2 apoptotic chromatin condensation inducer in the nucleus isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the mid coding region, compared to variant 1. The resulting isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AF168782, AK011698, AK050467, AK122342, BC094217

UniProtKB/TrEMBL

F6RJ39

Related

ENSMUSP00000119080.2, ENSMUST00000147714.8

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:998 → 1084

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1152 → 1227

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_001242605.1 → NP_001229534.1 apoptotic chromatin condensation inducer in the nucleus isoform 5

See identical proteins and their annotated locations for NP_001229534.1

Status: VALIDATED

Description

This variant (5) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.

Source sequence(s)

AF124729, BC094217, BY295579

Consensus CDS

CCDS56957.1

UniProtKB/TrEMBL

B8JJ92

Related

ENSMUSP00000114546.2, ENSMUST00000126166.8

Conserved Domains (2) summary

cd12432
Location:237 → 323

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:432 → 466

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_001242606.1 → NP_001229535.1 apoptotic chromatin condensation inducer in the nucleus isoform 6

See identical proteins and their annotated locations for NP_001229535.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks a 5' exon and uses an alternate splice site in the coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which is associated with a strong Kozak sequence.

Source sequence(s)

BC094217, BY295579

Consensus CDS

CCDS56956.1

UniProtKB/TrEMBL

Q52KR6

Related

ENSMUSP00000116664.2, ENSMUST00000141453.8

Conserved Domains (2) summary

cd12432
Location:224 → 310

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:419 → 453

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_001374770.1 → NP_001361699.1 apoptotic chromatin condensation inducer in the nucleus isoform 7

Status: VALIDATED

Source sequence(s)

CT009512

Consensus CDS

CCDS88664.1

UniProtKB/TrEMBL

F6RJ39

Related

ENSMUSP00000107109.3, ENSMUST00000111484.9

Conserved Domains (5) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:970 → 1056

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

TIGR01348
Location:373 → 507

PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam02463
Location:86 → 376

SMC_N; RecF/RecN/SMC N terminal domain

pfam16294
Location:1165 → 1199

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_019567.3 → NP_062513.3 apoptotic chromatin condensation inducer in the nucleus isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (1).

Source sequence(s)

AF124725, BC094217, BY295579, BY711288

Consensus CDS

CCDS27098.2

UniProtKB/TrEMBL

B8JJ91

Related

ENSMUSP00000118069.2, ENSMUST00000150371.8

Conserved Domains (2) summary

cd12432
Location:306 → 392

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:460 → 535

RSB_motif; RNSP1-SAP18 binding (RSB) motif
NM_023190.3 → NP_075679.2 apoptotic chromatin condensation inducer in the nucleus isoform 2

See identical proteins and their annotated locations for NP_075679.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AF168782, AK011698, AK030449, BC094217

Consensus CDS

CCDS27097.1

UniProtKB/Swiss-Prot

B8JJ87, Q9CSN7, Q9CSR9, Q9CSX7, Q9JIX8, Q9R046, Q9R047

UniProtKB/TrEMBL

F6RJ39

Related

ENSMUSP00000022793.9, ENSMUST00000022793.15

Conserved Domains (3) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:1010 → 1096

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:1164 → 1239

RSB_motif; RNSP1-SAP18 binding (RSB) motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

54879618..54924422 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247893.2 → XP_030103753.1 apoptotic chromatin condensation inducer in the nucleus isoform X3

UniProtKB/TrEMBL

F6RJ39

Conserved Domains (5) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:969 → 1055

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

TIGR01348
Location:373 → 507

PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam02463
Location:86 → 376

SMC_N; RecF/RecN/SMC N terminal domain

pfam16294
Location:1164 → 1198

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_030247894.2 → XP_030103754.1 apoptotic chromatin condensation inducer in the nucleus isoform X4

UniProtKB/TrEMBL

F6RJ39

Conserved Domains (5) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

cd12432
Location:958 → 1044

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

TIGR01348
Location:373 → 507

PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam02463
Location:86 → 376

SMC_N; RecF/RecN/SMC N terminal domain

pfam16294
Location:1153 → 1187

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_006519297.3 → XP_006519360.1 apoptotic chromatin condensation inducer in the nucleus isoform X2

UniProtKB/TrEMBL

F6RJ39

Conserved Domains (5) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PTZ00121
Location:210 → 416

PTZ00121; MAEBL; Provisional

cd12432
Location:997 → 1083

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

TIGR01348
Location:413 → 547

PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam16294
Location:1192 → 1226

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_006519296.3 → XP_006519359.1 apoptotic chromatin condensation inducer in the nucleus isoform X1

UniProtKB/TrEMBL

F6RJ39

Conserved Domains (5) summary

smart00513
Location:72 → 106

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PTZ00121
Location:210 → 416

PTZ00121; MAEBL; Provisional

cd12432
Location:1009 → 1095

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

TIGR01348
Location:413 → 547

PDHac_trf_long; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

pfam16294
Location:1204 → 1238

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_006519308.4 → XP_006519371.1 apoptotic chromatin condensation inducer in the nucleus isoform X9

See identical proteins and their annotated locations for XP_006519371.1

UniProtKB/TrEMBL

Q52KR6

Conserved Domains (2) summary

cd12432
Location:224 → 310

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:419 → 453

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_006519304.4 → XP_006519367.1 apoptotic chromatin condensation inducer in the nucleus isoform X8

See identical proteins and their annotated locations for XP_006519367.1

UniProtKB/TrEMBL

B8JJ92

Conserved Domains (2) summary

cd12432
Location:237 → 323

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:432 → 466

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_006519301.2 → XP_006519364.1 apoptotic chromatin condensation inducer in the nucleus isoform X5

Conserved Domains (2) summary

cd12432
Location:319 → 405

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:514 → 548

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_030247896.1 → XP_030103756.1 apoptotic chromatin condensation inducer in the nucleus isoform X7

Conserved Domains (2) summary

cd12432
Location:293 → 379

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:488 → 522

RSB_motif; RNSP1-SAP18 binding (RSB) motif
XM_030247895.1 → XP_030103755.1 apoptotic chromatin condensation inducer in the nucleus isoform X6

Conserved Domains (2) summary

cd12432
Location:306 → 392

RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins

pfam16294
Location:501 → 535

RSB_motif; RNSP1-SAP18 binding (RSB) motif