Klk8 kallikrein related-peptidase 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk8provided by MGI
Official Full Name: kallikrein related-peptidase 8provided by MGI
Primary source: MGI:MGI:1343327
See related: Ensembl:ENSMUSG00000064023 AllianceGenome:MGI:1343327
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NP; BSP1; Nrpn; Prss19
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
Expression: Broad expression in stomach adult (RPKM 16.0), thymus adult (RPKM 5.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43447001..43453250)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43797532..43803826)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
Title: Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1.
Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
Title: Genetic knockdown of Klk8 has sex-specific multi-targeted therapeutic effects on Alzheimer's pathology in mice.
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Title: A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Klk8 knockout mice (NRG1-deactivated mice) exhibited normal social approach but impaired social discrimination
Title: Impaired social discrimination behavior despite normal social approach by kallikrein-related peptidase 8 knockout mouse.
KLK8 deficiency in mouse hippocampus reduced L1CAM cleavage and MAP2c levels and caused profound loss of dendrites. Disruption of dendrite growth impaired novel object recognition memory in KLK8 compromised mice possibly via inhibition of PKA/CREB signaling.
Title: A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.
Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
Title: NGF-p75 and neuropsin/KLK8 pathways stimulate each other to cause hyperkeratosis and acanthosis in inflamed skin.
Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 in the late stages of wound healing.
Title: Kallikrein-related peptidase 8-dependent skin wound healing is associated with upregulation of kallikrein-related peptidase 6 and PAR2.
KLK8 is involved in synaptic tagging during LTP at basal and apical dendritic inputs.
Title: Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.
the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynamics of the EphB2-NMDA-receptor interaction, the expression of Fkbp5 and anxiety-like behaviour
Title: Neuropsin cleaves EphB2 in the amygdala to control anxiety.
Klk8 might thus be involved in tissue development and rearrangement.
Title: Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prss19 (e-PCR), detects polymorphism
- UniSTS:255290

Klk8 (e-PCR), detects polymorphism
- UniSTS:531088

AI324041 (e-PCR)
- UniSTS:159633

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kallikrein-8

Names: Brain Serine protease 1; protease, serine, 19 (neuropsin)

NP_001311327.1

EC 3.4.21.118

NP_032966.1

EC 3.4.21.118

XP_030098463.1

EC 3.4.21.118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001324398.1 → NP_001311327.1 kallikrein-8 preproprotein

Status: REVIEWED

Source sequence(s)

AB074296, AC151989, EH106421

Consensus CDS

CCDS21182.1

UniProtKB/Swiss-Prot

Q61955, Q8K5D7

UniProtKB/TrEMBL

A0A0B6VRH9, A0A0U1RNI7

Related

ENSMUSP00000145580.2, ENSMUST00000205537.2

Conserved Domains (1) summary

smart00020
Location:32 → 252

Tryp_SPc; Trypsin-like serine protease
NM_008940.3 → NP_032966.1 kallikrein-8 preproprotein

See identical proteins and their annotated locations for NP_032966.1

Status: REVIEWED

Source sequence(s)

AB074296, AC151989, EH106421

Consensus CDS

CCDS21182.1

UniProtKB/Swiss-Prot

Q61955, Q8K5D7

UniProtKB/TrEMBL

A0A0B6VRH9, A0A0U1RNI7

Related

ENSMUSP00000082588.3, ENSMUST00000085461.4

Conserved Domains (1) summary

smart00020
Location:32 → 252

Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43447001..43453250

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242603.2 → XP_030098463.1 kallikrein-8 isoform X1

Conserved Domains (1) summary

smart00020
Location:1 → 131

Tryp_SPc; Trypsin-like serine protease