Xpo5 exportin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xpo5provided by MGI
Official Full Name: exportin 5provided by MGI
Primary source: MGI:MGI:1913789
See related: Ensembl:ENSMUSG00000067150 AllianceGenome:MGI:1913789
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Exp5; RanBp21; mKIAA1291; 2410004H11Rik; 2700038C24Rik
Summary: Enables nuclear export signal receptor activity and tRNA binding activity. Acts upstream of or within protein export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC complex and RNA nuclear export complex. Predicted to be active in cytoplasm and nucleus. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and head. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Orthologous to human XPO5 (exportin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.1), CNS E14 (RPKM 15.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 22.9 cM; 17 C

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46513737..46554524)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46202811..46243598)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

productive reoviral infection is strongly correlated with elevated importin-beta and exportin-5 levels which may serve as biomarkers of the disease in clinical specimens
Title: Importin-β and exportin-5 are strong biomarkers of productive reoviral infection of cancer cells.
miRNA biogenesis components Drosha, Dgcr8, Exportin-5 and Dicer1 are expressed in the mouse uterus and that Exportin-5 and Dicer1 appear to be the major steroid regulated components in the miRNA biogenesis pathway
Title: Steroidal regulation of uterine miRNAs is associated with modulation of the miRNA biogenesis components Exportin-5 and Dicer1.
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI648907 (e-PCR)
- UniSTS:164625

MARC_10377-10378:999102157:1 (e-PCR)
- UniSTS:267123

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RISC complex binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear export signal receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear export	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-miRNA export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	ISO Inferred from Sequence Orthology more info
part_of RNA nuclear export complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA nuclear export complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exportin-5

Names: ran-binding protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028198.3 → NP_082474.1 exportin-5

Status: VALIDATED

Source sequence(s)

AC116739

Consensus CDS

CCDS37631.1

UniProtKB/Swiss-Prot

A2RRJ5, Q7TMP2, Q80TF9, Q924C1, Q9CRI9, Q9CT48

UniProtKB/TrEMBL

A2RRJ4

Related

ENSMUSP00000084257.6, ENSMUST00000087031.7

Conserved Domains (2) summary

smart00913
Location:33 → 100

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:109 → 271

Xpo1; Exportin 1-like protein