Dhrs9 dehydrogenase/reductase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhrs9provided by MGI
Official Full Name: dehydrogenase/reductase 9provided by MGI
Primary source: MGI:MGI:2442798
See related: Ensembl:ENSMUSG00000027068 AllianceGenome:MGI:2442798
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rdh15; C730025I08Rik
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in 9-cis-retinoic acid biosynthetic process; androgen metabolic process; and progesterone metabolic process. Predicted to act upstream of or within steroid metabolic process. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human DHRS9 (dehydrogenase/reductase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 6.0), colon adult (RPKM 1.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 40.59 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (69210806..69233430)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (69380462..69403086)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 9

Names: 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha-HSD; dehydrogenase/reductase (SDR family) member 9; epithelial retinol dehydrogenase; retinol dehydrogenase; short-chain dehydrogenase/reductase retSDR8

NP_780721.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175512.2 → NP_780721.1 dehydrogenase/reductase SDR family member 9 precursor

See identical proteins and their annotated locations for NP_780721.1

Status: PROVISIONAL

Source sequence(s)

AK080914

Consensus CDS

CCDS16091.1

UniProtKB/Swiss-Prot

Q58NB6, Q8BGC7

UniProtKB/TrEMBL

Q148Q4

Related

ENSMUSP00000069631.4, ENSMUST00000063690.4

Conserved Domains (1) summary

cd09805
Location:30 → 306

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs