Odad2 outer dynein arm docking complex subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odad2provided by MGI
Official Full Name: outer dynein arm docking complex subunit 2provided by MGI
Primary source: MGI:MGI:1922184
See related: Ensembl:ENSMUSG00000061802 AllianceGenome:MGI:1922184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Armc4; b2b643Clo; b2b227.1Clo; 4930463I21Rik
Summary: Acts upstream of or within several processes, including cilium movement; outer dynein arm assembly; and ventricular system development. Predicted to be located in axoneme and ciliary base. Is expressed in node. Used to study Kartagener syndrome; primary ciliary dyskinesia 23; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 5.0) and ovary adult (RPKM 0.3) See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.53 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (7088233..7298272, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (7088233..7298273, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.
Title: ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.
Armc4 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225088

AU048067 (e-PCR)
- UniSTS:109905

D18Mit18 (e-PCR), detects polymorphism
- UniSTS:116567

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outer dynein arm assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cilium beat frequency	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: outer dynein arm-docking complex subunit 2

Names: armadillo repeat containing 4; armadillo repeat-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357492.1 → NP_001344421.1 outer dynein arm-docking complex subunit 2

Status: VALIDATED

Source sequence(s)

BB573298, BB679543, BC158097

Consensus CDS

CCDS37729.1

UniProtKB/Swiss-Prot

B2RY50, Q9CUL6

Related

ENSMUSP00000157197.2, ENSMUST00000234788.2

Conserved Domains (4) summary

PLN03200
Location:618 → 855

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:750 → 1035

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:919 → 947

HEAT; HEAT repeat [structural motif]

sd00043
Location:876 → 901

ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

7088233..7298272 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526313.5 → XP_006526376.1 outer dynein arm-docking complex subunit 2 isoform X3

Conserved Domains (4) summary

PLN03200
Location:473 → 710

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:605 → 890

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:774 → 802

HEAT; HEAT repeat [structural motif]

sd00043
Location:731 → 756

ARM; armadillo repeat [structural motif]
XM_036161300.1 → XP_036017193.1 outer dynein arm-docking complex subunit 2 isoform X2

Conserved Domains (4) summary

PLN03200
Location:494 → 731

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:626 → 911

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:795 → 823

HEAT; HEAT repeat [structural motif]

sd00043
Location:752 → 777

ARM; armadillo repeat [structural motif]
XM_030250622.1 → XP_030106482.1 outer dynein arm-docking complex subunit 2 isoform X1

UniProtKB/Swiss-Prot

B2RY50, Q9CUL6

Related

ENSMUSP00000080028.5, ENSMUST00000081275.5

Conserved Domains (4) summary

PLN03200
Location:618 → 855

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:750 → 1035

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00044
Location:919 → 947

HEAT; HEAT repeat [structural motif]

sd00043
Location:876 → 901

ARM; armadillo repeat [structural motif]
XM_011247017.1 → XP_011245319.1 outer dynein arm-docking complex subunit 2 isoform X5

Conserved Domains (3) summary

PLN03200
Location:167 → 404

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:299 → 584

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:459 → 488

ARM; armadillo repeat [structural motif]
XM_011247016.1 → XP_011245318.1 outer dynein arm-docking complex subunit 2 isoform X4

Conserved Domains (3) summary

PLN03200
Location:312 → 549

PLN03200; cellulose synthase-interactive protein; Provisional

COG5064
Location:444 → 729

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:604 → 633

ARM; armadillo repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081393.1: Suppressed sequence

Description

NM_001081393.1: This RefSeq was removed because currently there is insufficient support for the transcript.