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    Lactb2 lactamase, beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 212442, updated on 25-May-2024

    Summary

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    Official Symbol
    Lactb2provided by MGI
    Official Full Name
    lactamase, beta 2provided by MGI
    Primary source
    MGI:MGI:2442551
    See related
    Ensembl:ENSMUSG00000025937 AllianceGenome:MGI:2442551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgi-83; E430032H21Rik
    Summary
    Predicted to enable endoribonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Located in mitochondrion. Is expressed in brain ventricular layer; liver lobe; lung; renal cortex; and submandibular gland primordium. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 64.2), liver adult (RPKM 44.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lactb2 in Genome Data Viewer
    Location:
    1 A3; 1 4.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13695069..13730749, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13625893..13660583, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00273 Neighboring gene predicted gene, 39600 Neighboring gene STARR-seq mESC enhancer starr_00275 Neighboring gene STARR-seq mESC enhancer starr_00276 Neighboring gene STARR-seq mESC enhancer starr_00277 Neighboring gene STARR-seq mESC enhancer starr_00278 Neighboring gene translocating chain-associating membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_00279 Neighboring gene STARR-seq mESC enhancer starr_00283 Neighboring gene STARR-seq mESC enhancer starr_00284 Neighboring gene X-linked Kx blood group related 9 Neighboring gene predicted gene, 26273

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Sollars VE, et al. Hum Mol Genet, 2002 Oct 15. PMID 12374767
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7674

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    endoribonuclease LACTB2
    Names
    beta-lactamase-like protein 2
    NP_001404559.1
    NP_001404562.1
    NP_001404563.1
    NP_001404564.1
    NP_001404565.1
    NP_663356.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417630.1 → NP_001404559.1  endoribonuclease LACTB2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116708

    2. NM_001417633.1 → NP_001404562.1  endoribonuclease LACTB2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116708

    3. NM_001417634.1 → NP_001404563.1  endoribonuclease LACTB2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116708

    4. NM_001417635.1 → NP_001404564.1  endoribonuclease LACTB2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116708

    5. NM_001417636.1 → NP_001404565.1  endoribonuclease LACTB2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116708

    6. NM_145381.3 → NP_663356.1  endoribonuclease LACTB2 isoform 1

      See identical proteins and their annotated locations for NP_663356.1

      Status: VALIDATED

      Source sequence(s)
      AC116708
      Consensus CDS
      CCDS14823.1
      UniProtKB/Swiss-Prot
      Q99KR3
      Related
      ENSMUSP00000027071.6, ENSMUST00000027071.7
      Conserved Domains (2) summary
      COG0491
      Location:23 → 223
      GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
      cd07722
      Location:14 → 203
      LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain

    RNA

    1. NR_184544.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116708

    2. NR_184545.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116708

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      13695069..13730749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KR3.1 GenPept UniProtKB/Swiss-Prot:Q99KR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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