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    Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 [ Mus musculus (house mouse) ]

    Gene ID: 233005, updated on 8-Feb-2024

    Summary

    Official Symbol
    Cyp2a22provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily a, polypeptide 22provided by MGI
    Primary source
    MGI:MGI:3648316
    See related
    Ensembl:ENSMUSG00000091867 AllianceGenome:MGI:3648316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG233005
    Summary
    Predicted to enable enzyme binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in coumarin metabolic process; epoxygenase P450 pathway; and xenobiotic metabolic process. Predicted to be located in cytoplasmic microtubule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in nicotine dependence and warfarin resistance. Orthologous to human CYP2A13 (cytochrome P450 family 2 subfamily A member 13); CYP2A6 (cytochrome P450 family 2 subfamily A member 6); and CYP2A7 (cytochrome P450 family 2 subfamily A member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward liver adult (RPKM 52.9) See more
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    Genomic context

    See Cyp2a22 in Genome Data Viewer
    Location:
    7 A3; 7 15.65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26631564..26638838, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26931631..26939413, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Cyp2a5 5' regulatory region Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 5 Neighboring gene predicted gene, 57503 Neighboring gene apoptosis inhibitor 5, pseudogene Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18341 Neighboring gene STARR-seq mESC enhancer starr_18342 Neighboring gene cytochrome P450, family 2, subfamily a, polypeptide 12 Neighboring gene predicted gene, 51444

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in coumarin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytochrome P450, family 2, subfamily a, polypeptide 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101467.2NP_001094937.1  cytochrome P450, family 2, subfamily a, polypeptide 22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001094937.1

      Status: VALIDATED

      Source sequence(s)
      AC167659
      Consensus CDS
      CCDS52156.1
      UniProtKB/TrEMBL
      B2RXZ2
      Related
      ENSMUSP00000128030.2, ENSMUST00000170227.3
      Conserved Domains (1) summary
      pfam00067
      Location:33489
      p450; Cytochrome P450
    2. NM_001421745.1NP_001408674.1  cytochrome P450, family 2, subfamily a, polypeptide 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167659
    3. NM_001421746.1NP_001408675.1  cytochrome P450, family 2, subfamily a, polypeptide 22 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC167659

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26631564..26638838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539859.3XP_006539922.1  cytochrome P450, family 2, subfamily a, polypeptide 22 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:33431
      p450; Cytochrome P450