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    Atp6v1g2 ATPase, H+ transporting, lysosomal V1 subunit G2 [ Mus musculus (house mouse) ]

    Gene ID: 66237, updated on 12-May-2024

    Summary

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    Official Symbol
    Atp6v1g2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V1 subunit G2provided by MGI
    Primary source
    MGI:MGI:1913487
    See related
    Ensembl:ENSMUSG00000024403 AllianceGenome:MGI:1913487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NG38; VAG2; Atp6g2; 1500002D01Rik
    Summary
    Enables ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to act upstream of or within ion transport. Is integral component of synaptic vesicle membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including nervous system. Orthologous to human ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 155.4), frontal lobe adult (RPKM 143.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp6v1g2 in Genome Data Viewer
    Location:
    17 B1; 17 18.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35453910..35457743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35234931..35238767)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35337508-35337695 Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene STARR-positive B cell enhancer ABC_E11642 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5601 Neighboring gene STARR-positive B cell enhancer ABC_E7528 Neighboring gene STARR-positive B cell enhancer ABC_E1942 Neighboring gene STARR-positive B cell enhancer ABC_E10948 Neighboring gene DEAD box helicase 39b Neighboring gene predicted gene, 22589 Neighboring gene microRNA 6975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain. Kawamura N, et al. Sci Rep, 2015 Sep 10. PMID 26353914, Free PMC Article
    2. Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons. Murata Y, et al. J Biol Chem, 2002 Sep 27. PMID 12133826
    3. The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery. Bodzęta A, et al. Cell Rep, 2017 Aug 8. PMID 28793259
    4. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
    5. Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage. Yao W, et al. J Neurosci, 2019 Aug 28. PMID 31235642, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. V-ATPase G1 and G2 isoforms are expressed in mouse embryo neurons and are involved in synaptic vesicle acidification
      Title: Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle lumen acidification EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle lumen acidification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit G 2
    Names
    ATPase, H+ transporting, V1 subunit G
    ATPase, H+ transporting, lysosomal (vacuolar proton pump)
    ATPase, H+ transporting, lysosomal 13kD, V1 subunit G
    V-ATPase 13 kDa subunit 2
    V-ATPase subunit G 2
    lysosomal 13kDa
    vacuolar proton pump subunit G 2
    NP_001334280.1
    NP_075668.1
    XP_006524858.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347351.1 → NP_001334280.1  V-type proton ATPase subunit G 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC020190, CR974444
      Consensus CDS
      CCDS84301.1
      UniProtKB/TrEMBL
      B0V2H4, G5E923
      Related
      ENSMUSP00000134733.2, ENSMUST00000130992.2
      Conserved Domains (1) summary
      cl03922
      Location:1 → 66
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    2. NM_023179.3 → NP_075668.1  V-type proton ATPase subunit G 2 isoform 1

      See identical proteins and their annotated locations for NP_075668.1

      Status: VALIDATED

      Source sequence(s)
      BC020190, BU558667
      Consensus CDS
      CCDS37597.1
      UniProtKB/Swiss-Prot
      Q9WTT4
      UniProtKB/TrEMBL
      Q54A87
      Related
      ENSMUSP00000069482.9, ENSMUST00000068261.9
      Conserved Domains (1) summary
      pfam03179
      Location:3 → 107
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35453910..35457743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524795.4 → XP_006524858.1  V-type proton ATPase subunit G 2 isoform X1

      See identical proteins and their annotated locations for XP_006524858.1

      UniProtKB/TrEMBL
      B0V2H4, G5E923
      Conserved Domains (1) summary
      cl03922
      Location:1 → 66
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTT4.1 GenPept UniProtKB/Swiss-Prot:Q9WTT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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