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    Fndc3a fibronectin type III domain containing 3A [ Mus musculus (house mouse) ]

    Gene ID: 319448, updated on 12-May-2024

    Summary

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    Official Symbol
    Fndc3aprovided by MGI
    Official Full Name
    fibronectin type III domain containing 3Aprovided by MGI
    Primary source
    MGI:MGI:1196463
    See related
    Ensembl:ENSMUSG00000033487 AllianceGenome:MGI:1196463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sys; Fndc3; D14Ertd453e; 1700094E19Rik; F730017H24Rik
    Summary
    Acts upstream of or within several processes, including Sertoli cell development; fertilization; and spermatid development. Located in acrosomal vesicle; cytosol; and vesicle membrane. Is expressed in brain; inner ear; limb; and submandibular gland primordium. Orthologous to human FNDC3A (fibronectin type III domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.1), placenta adult (RPKM 12.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fndc3a in Genome Data Viewer
    Location:
    14 D2; 14 37.62 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (72775388..72948141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (72537948..72710701, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30500 Neighboring gene motilin receptor, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8898 Neighboring gene STARR-seq mESC enhancer starr_37102 Neighboring gene STARR-seq mESC enhancer starr_37103 Neighboring gene STARR-seq mESC enhancer starr_37104 Neighboring gene predicted gene, 35218 Neighboring gene STARR-seq mESC enhancer starr_37105 Neighboring gene predicted gene 4606 Neighboring gene predicted gene, 41206

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis structure in the sys (symplastic spermatids) mouse. Russell LD, et al. Am J Anat, 1991 Oct. PMID 1759682
    2. FNDC3A is required for adhesion between spermatids and Sertoli cells. Obholz KL, et al. Dev Biol, 2006 Oct 15. PMID 16904100, Free PMC Article
    3. Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. MacGregor GR, et al. Proc Natl Acad Sci U S A, 1990 Jul. PMID 2164218, Free PMC Article
    4. Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14. Tzimagiorgis G, et al. Genomics, 1991 May. PMID 2045113
    5. Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14. Kozak CA, et al. Genomics, 1991 Apr. PMID 2037301

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Associated conditions

    Description Tests
    symplastic spermatids
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibronectin type-III domain-containing protein 3A
    Names
    fibronectin domain-containing protein 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207636.3 → NP_997519.2  fibronectin type-III domain-containing protein 3A

      See identical proteins and their annotated locations for NP_997519.2

      Status: VALIDATED

      Source sequence(s)
      AC158981, AC165423, CT010579
      Consensus CDS
      CCDS27264.1
      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Related
      ENSMUSP00000086411.6, ENSMUST00000089017.12
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      72775388..72948141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519115.5 → XP_006519178.2  fibronectin type-III domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006519178.2

      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_036158666.1 → XP_036014559.1  fibronectin type-III domain-containing protein 3A isoform X1

      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_030247858.2 → XP_030103718.1  fibronectin type-III domain-containing protein 3A isoform X4

      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:307 → 398
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_006519116.5 → XP_006519179.1  fibronectin type-III domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006519179.1

      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_030247857.2 → XP_030103717.1  fibronectin type-III domain-containing protein 3A isoform X1

      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. XM_036158665.1 → XP_036014558.1  fibronectin type-III domain-containing protein 3A isoform X1

      UniProtKB/Swiss-Prot
      Q2VEY7, Q3T9K5, Q6ZQ15, Q811D3, Q8BME4, Q8BTM3, Q8BX90
      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:371 → 462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. XM_017316055.3 → XP_017171544.1  fibronectin type-III domain-containing protein 3A isoform X2

      UniProtKB/TrEMBL
      F6TLV3
      Conserved Domains (1) summary
      cd00063
      Location:348 → 439
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    8. XM_006519118.5 → XP_006519181.1  fibronectin type-III domain-containing protein 3A isoform X3

      UniProtKB/TrEMBL
      F6TLV3
      Related
      ENSMUSP00000124218.2, ENSMUST00000162825.8
      Conserved Domains (1) summary
      cd00063
      Location:315 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX90.3 GenPept UniProtKB/Swiss-Prot:Q8BX90

    Gene LinkOut

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