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    Slc41a1 solute carrier family 41, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 98396, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Slc41a1provided by MGI
    Official Full Name
    solute carrier family 41, member 1provided by MGI
    Primary source
    MGI:MGI:2444823
    See related
    Ensembl:ENSMUSG00000013275 AllianceGenome:MGI:2444823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230315F01Rik
    Summary
    Enables inorganic cation transmembrane transporter activity. Involved in cellular response to magnesium ion and magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; mesenteric adipose tissue; and respiratory system. Orthologous to human SLC41A1 (solute carrier family 41 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 28.8), heart adult (RPKM 25.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc41a1 in Genome Data Viewer
    Location:
    1 E4; 1 57.2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131755236..131776601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131828012..131848863)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 9 Neighboring gene STARR-seq mESC enhancer starr_02224 Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene RAB29, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC41A1 knockout mice display normal magnesium homeostasis. Ilenwabor BP, et al. Am J Physiol Renal Physiol, 2022 Nov 1. PMID 36049064
    2. Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes. Tatarkova Z, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153064, Free PMC Article
    3. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Tsao YT, et al. Stem Cell Res Ther, 2017 Feb 21. PMID 28222767, Free PMC Article
    4. Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux system. Mastrototaro L, et al. Sci Rep, 2016 Jun 15. PMID 27302215, Free PMC Article
    5. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Zocchi M, et al. Int J Mol Sci, 2022 Jan 31. PMID 35163580, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC41A1 knockout mice display normal magnesium homeostasis.
      Title: SLC41A1 knockout mice display normal magnesium homeostasis.
    2. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
      Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
    3. Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
      Title: Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes.
    4. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
      Title: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inorganic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in magnesium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 41 member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173865.3 → NP_776290.1  solute carrier family 41 member 1

      See identical proteins and their annotated locations for NP_776290.1

      Status: VALIDATED

      Source sequence(s)
      AC161805, BC037033, BC116280
      Consensus CDS
      CCDS15275.1
      UniProtKB/Swiss-Prot
      Q8BJA2
      Related
      ENSMUSP00000083747.7, ENSMUST00000086559.7
      Conserved Domains (1) summary
      pfam01769
      Location:138 → 269
      MgtE; Divalent cation transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131755236..131776601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154630.1 → XP_036010523.1  solute carrier family 41 member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BJA2
      Conserved Domains (1) summary
      pfam01769
      Location:138 → 269
      MgtE; Divalent cation transporter

    2. XM_036154631.1 → XP_036010524.1  solute carrier family 41 member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BJA2
      Conserved Domains (1) summary
      pfam01769
      Location:138 → 269
      MgtE; Divalent cation transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJA2.1 GenPept UniProtKB/Swiss-Prot:Q8BJA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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