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    Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287406, updated on 2-May-2024

    Summary

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    Official Symbol
    Adprmprovided by RGD
    Official Full Name
    ADP-ribose/CDP-alcohol diphosphatase, manganese-dependentprovided by RGD
    Primary source
    RGD:1309906
    See related
    Ensembl:ENSRNOG00000003397 AllianceGenome:RGD:1309906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MDS006; RGD1309906; ADPRibase-Mn
    Summary
    Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Orthologous to human ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 134.4), Spleen (RPKM 133.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adprm in Genome Data Viewer
    Location:
    10q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52231085..52243637, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51732073..51744635, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53583275..53595821, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 like Neighboring gene uncharacterized LOC134480699 Neighboring gene transmembrane protein 220 Neighboring gene synthesis of cytochrome C oxidase 1 Neighboring gene myosin heavy chain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase. Canales J, et al. FEBS Lett, 2009 May 19. PMID 19379742
    2. Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells. Canales J, et al. Biochem J, 2008 Jul 1. PMID 18352857
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The phosphoanhydride bond of cyclic ADP-ribose or cADPR is hydrolyzed by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
      Title: Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
    2. The structure and function of Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase in immune tissues are reported.
      Title: Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108803

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-glycerol diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Names
    CDP-choline phosphohydrolase
    liver manganese (II)-dependent ADP-ribose/CDP-alcohol pyrophosphatase
    NP_001009246.1
    XP_006246665.1
    XP_006246666.1
    XP_063124700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009246.1 → NP_001009246.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

      See identical proteins and their annotated locations for NP_001009246.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088174
      UniProtKB/Swiss-Prot
      A9Y0H8, Q5M886
      UniProtKB/TrEMBL
      A0A8I5ZXR4, A6HFH4
      Conserved Domains (2) summary
      cd07396
      Location:18 → 322
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
      pfam00149
      Location:69 → 280
      Metallophos; Calcineurin-like phosphoesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52231085..52243637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246603.4 → XP_006246665.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1

      See identical proteins and their annotated locations for XP_006246665.1

      UniProtKB/Swiss-Prot
      A9Y0H8, Q5M886
      UniProtKB/TrEMBL
      A0A8I5ZXR4, A6HFH4
      Related
      ENSRNOP00000084290.1, ENSRNOT00000108244.1
      Conserved Domains (2) summary
      cd07396
      Location:18 → 322
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
      pfam00149
      Location:69 → 280
      Metallophos; Calcineurin-like phosphoesterase

    2. XM_006246604.5 → XP_006246666.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q2A8
      Related
      ENSRNOP00000004560.4
      Conserved Domains (2) summary
      pfam00149
      Location:69 → 114
      Metallophos; Calcineurin-like phosphoesterase
      cl13995
      Location:18 → 253
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    3. XM_063268630.1 → XP_063124700.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X3

      UniProtKB/TrEMBL
      A6HFH5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M886.1 GenPept UniProtKB/Swiss-Prot:Q5M886

    Gene LinkOut

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