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    Padi1 peptidyl arginine deiminase, type I [ Mus musculus (house mouse) ]

    Gene ID: 18599, updated on 4-May-2024

    Summary

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    Official Symbol
    Padi1provided by MGI
    Official Full Name
    peptidyl arginine deiminase, type Iprovided by MGI
    Primary source
    MGI:MGI:1338893
    See related
    Ensembl:ENSMUSG00000025329 AllianceGenome:MGI:1338893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdi1
    Summary
    Predicted to enable calcium ion binding activity and protein-arginine deiminase activity. Predicted to be involved in histone citrullination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; and oocyte. Orthologous to human PADI1 (peptidyl arginine deiminase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 15.4), subcutaneous fat pad adult (RPKM 3.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D3; 4 72.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140540292..140573089, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140812981..140845778, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140306464-140306665 Neighboring gene peptidyl arginine deiminase, type IV Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:140338844-140339025 Neighboring gene predicted gene, 52482 Neighboring gene peptidyl arginine deiminase, type III Neighboring gene predicted gene 13032 Neighboring gene STARR-seq mESC enhancer starr_11880 Neighboring gene RIKEN cDNA 4930515B02 gene Neighboring gene STARR-seq mESC enhancer starr_11881 Neighboring gene predicted gene, 46719 Neighboring gene peptidyl arginine deiminase, type II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I. Guerrin M, et al. Biochem J, 2003 Feb 15. PMID 12416996, Free PMC Article
    2. Three types of mouse peptidylarginine deiminase: characterization and tissue distribution. Terakawa H, et al. J Biochem, 1991 Oct. PMID 1778991
    3. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Zhang X, et al. Sci Rep, 2016 Dec 8. PMID 27929094, Free PMC Article
    4. Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse. Rus'd AA, et al. Eur J Biochem, 1999 Feb. PMID 10092850
    5. Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Chavanas S, et al. Gene, 2004 Apr 14. PMID 15087120

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine deiminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine deiminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine deiminase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-arginine deiminase type-1
    Names
    PAD type I
    PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE DEIMINASE I)
    Pad type 1
    peptidylarginine deiminase I
    NP_035189.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011059.2 → NP_035189.1  protein-arginine deiminase type-1

      See identical proteins and their annotated locations for NP_035189.1

      Status: PROVISIONAL

      Source sequence(s)
      AL807805
      Consensus CDS
      CCDS18856.1
      UniProtKB/Swiss-Prot
      Q9Z185
      UniProtKB/TrEMBL
      Q544I4
      Related
      ENSMUSP00000026378.4, ENSMUST00000026378.4
      Conserved Domains (3) summary
      pfam03068
      Location:283 → 659
      PAD; Protein-arginine deiminase (PAD)
      pfam08526
      Location:1 → 113
      PAD_N; Protein-arginine deiminase (PAD) N-terminal domain
      pfam08527
      Location:115 → 260
      PAD_M; Protein-arginine deiminase (PAD) middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      140540292..140573089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z185.1 GenPept UniProtKB/Swiss-Prot:Q9Z185

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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