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    Gbp11 guanylate binding protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 634650, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gbp11provided by MGI
    Official Full Name
    guanylate binding protein 11provided by MGI
    Primary source
    MGI:MGI:3646307
    See related
    Ensembl:ENSMUSG00000092021 AllianceGenome:MGI:3646307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm7141; EG634650
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular response to interferon-gamma; defense response to Gram-positive bacterium; and defense response to protozoan. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Broad expression in liver adult (RPKM 2.1), thymus adult (RPKM 2.0) and 22 other tissues See more
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    Genomic context

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    See Gbp11 in Genome Data Viewer
    Location:
    5 E5; 5 50.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105470892..105494342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105323026..105346476, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31785 Neighboring gene guanylate-binding protein 10 Neighboring gene STARR-seq mESC enhancer starr_13849 Neighboring gene guanylate binding protein 6 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene STARR-positive B cell enhancer ABC_E8067 Neighboring gene predicted gene, 26519 Neighboring gene predicted gene, 32051

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Clone Names

    • MGC117932

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanylate binding protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039647.3 → NP_001034736.3  guanylate binding protein 11

      See identical proteins and their annotated locations for NP_001034736.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.
      Source sequence(s)
      BC111039, BI655333
      UniProtKB/TrEMBL
      Q2TA93
      Conserved Domains (3) summary
      pfam02841
      Location:281 → 575
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:16 → 279
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:287 → 575
      GBP_C; Guanylate-binding protein, C-terminal domain

    RNA

    1. NR_132129.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.
      Source sequence(s)
      AC113980, BF470780
      Related
      ENSMUST00000100960.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105470892..105494342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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