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    Acnat1 acyl-coenzyme A amino acid N-acyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 230161, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Acnat1provided by MGI
    Official Full Name
    acyl-coenzyme A amino acid N-acyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2140197
    See related
    Ensembl:ENSMUSG00000070985 AllianceGenome:MGI:2140197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables N-acyltransferase activity. Involved in fatty acid metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 10.5), kidney adult (RPKM 8.0) and 6 other tissues See more
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    Genomic context

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    See Acnat1 in Genome Data Viewer
    Location:
    4 B1; 4 26.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49443532..49481315, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49443532..49481315, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A amino acid N-acyltransferase 2 Neighboring gene predicted gene 12451 Neighboring gene predicted gene 12452 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_10182 Neighboring gene STARR-seq mESC enhancer starr_10183 Neighboring gene STARR-seq mESC enhancer starr_10184 Neighboring gene predicted gene, 26424 Neighboring gene predicted gene, 33009 Neighboring gene predicted gene, 32894 Neighboring gene bile acid-Coenzyme A: amino acid N-acyltransferase Neighboring gene predicted gene, 52736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids. Reilly SJ, et al. FASEB J, 2007 Jan. PMID 17116739
    2. Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. Hunt MC, et al. Prog Lipid Res, 2008 Nov. PMID 18538142
    3. Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways. Narayan SB, et al. PLoS One, 2012. PMID 22496890, Free PMC Article
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A amino acid N-acyltransferase 1
    NP_001158037.1
    XP_006537902.1
    XP_006537903.1
    XP_006537905.1
    XP_006537906.1
    XP_011248302.1
    XP_011248304.1
    XP_011248305.1
    XP_011248306.1
    XP_011248307.1
    XP_030109278.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164565.1 → NP_001158037.1  acyl-coenzyme A amino acid N-acyltransferase 1

      See identical proteins and their annotated locations for NP_001158037.1

      Status: VALIDATED

      Source sequence(s)
      AL772310
      Consensus CDS
      CCDS51174.1
      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Related
      ENSMUSP00000092702.3, ENSMUST00000095086.3
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      49443532..49481315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250005.3 → XP_011248307.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_011248307.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    2. XM_011250004.3 → XP_011248306.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_011248306.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    3. XM_011250002.3 → XP_011248304.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_011248304.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    4. XM_006537842.4 → XP_006537905.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006537905.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    5. XM_006537843.4 → XP_006537906.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006537906.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    6. XM_006537840.4 → XP_006537903.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006537903.1

      Conserved Domains (2) summary
      pfam08840
      Location:221 → 425
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:29 → 154
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    7. XM_006537839.4 → XP_006537902.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006537902.1

      Conserved Domains (2) summary
      pfam08840
      Location:221 → 425
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:29 → 154
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    8. XM_011250003.3 → XP_011248305.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_011248305.1

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    9. XM_011250000.3 → XP_011248302.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_011248302.1

      Conserved Domains (2) summary
      pfam08840
      Location:221 → 425
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:29 → 154
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

    10. XM_030253418.1 → XP_030109278.1  acyl-coenzyme A amino acid N-acyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      A2AKK4, A2AKK5, Q0QBA1
      Conserved Domains (2) summary
      pfam08840
      Location:207 → 411
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:15 → 140
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AKK5.1 GenPept UniProtKB/Swiss-Prot:A2AKK5

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