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    Cnot8 CCR4-NOT transcription complex, subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 69125, updated on 12-May-2024

    Summary

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    Official Symbol
    Cnot8provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 8provided by MGI
    Primary source
    MGI:MGI:1916375
    See related
    Ensembl:ENSMUSG00000020515 AllianceGenome:MGI:1916375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500015I04Rik; 1810022F04Rik
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be located in nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human CNOT8 (CCR4-NOT transcription complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 34.1), CNS E14 (RPKM 23.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnot8 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57983620..58009423)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58092794..58118597)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29589 Neighboring gene STARR-positive B cell enhancer ABC_E8407 Neighboring gene STARR-positive B cell enhancer ABC_E10676 Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene STARR-seq mESC enhancer starr_29598 Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene predicted gene, 51897 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E10677 Neighboring gene STARR-seq mESC enhancer starr_29600 Neighboring gene predicted gene 12247 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E5229 Neighboring gene mitochondrial ribosomal protein L22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex. Stoney PN, et al. J Mol Biol, 2022 May 15. PMID 35248544
    2. The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs. Pasternak M, et al. Open Biol, 2016 Sep. PMID 27605379, Free PMC Article
    3. Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition. Quan Y, et al. Nucleic Acids Res, 2022 May 6. PMID 35390160, Free PMC Article
    4. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. Mostafa D, et al. RNA Biol, 2020 Mar. PMID 31924127, Free PMC Article
    5. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Chen C, et al. Biochem Biophys Res Commun, 2011 Jul 29. PMID 21741365

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
      Title: CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex.
    2. Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition.
      Title: Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition.
    3. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
      Title: Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
    4. study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
      Title: The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 8
    Names
    CCR4-associated factor 8
    NP_001343406.1
    NP_001350013.1
    NP_001350014.1
    NP_001350015.1
    NP_081225.1
    XP_006534165.1
    XP_036012844.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356477.2 → NP_001343406.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AK007581, AK075727, AK150757, BY419531
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Related
      ENSMUSP00000104471.2, ENSMUST00000108843.8
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    2. NM_001363084.1 → NP_001350013.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182, BB843287
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    3. NM_001363085.1 → NP_001350014.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    4. NM_001363086.1 → NP_001350015.1  CCR4-NOT transcription complex subunit 8

      Status: VALIDATED

      Source sequence(s)
      AL672182
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    5. NM_026949.5 → NP_081225.1  CCR4-NOT transcription complex subunit 8

      See identical proteins and their annotated locations for NP_081225.1

      Status: VALIDATED

      Source sequence(s)
      AK075727, AK150757, BY419531, CD553562
      Consensus CDS
      CCDS24722.1
      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Related
      ENSMUSP00000020822.6, ENSMUST00000020822.12
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      57983620..58009423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534102.2 → XP_006534165.1  CCR4-NOT transcription complex subunit 8 isoform X1

      See identical proteins and their annotated locations for XP_006534165.1

      UniProtKB/Swiss-Prot
      Q3U532, Q9D8X5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 263
      CAF1; CAF1 family ribonuclease

    2. XM_036156951.1 → XP_036012844.1  CCR4-NOT transcription complex subunit 8 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8X5.1 GenPept UniProtKB/Swiss-Prot:Q9D8X5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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