Hspa12b heat shock protein 12B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa12bprovided by MGI
Official Full Name: heat shock protein 12Bprovided by MGI
Primary source: MGI:MGI:1919880
See related: Ensembl:ENSMUSG00000074793 AllianceGenome:MGI:1919880
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700081N06Rik
Summary: Predicted to enable ATP binding activity. Is expressed in nervous system; retina; smooth muscle tissue; and stomach. Orthologous to human HSPA12B (heat shock protein family A (Hsp70) member 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 21.1), subcutaneous fat pad adult (RPKM 16.9) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2 F1; 2 63.27 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (130969332..130987905)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (131127412..131145985)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS.
Title: LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B EXPRESSION VIA GPR81-DEPENDENT SIGNALING IN SEPSIS.
Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction.
Title: Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction.
Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.
Title: Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating Macrophage Inflammatory Responses in Polymicrobial Sepsis.
Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
Title: Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
HSPA12B promoted functional recovery and survival after stroke in an eNOS-dependent mechanism.
Title: HSPA12B promotes functional recovery after ischaemic stroke through an eNOS-dependent mechanism.
These results demonstrate a pulmonary protective effect of HSPA12B against endotoxin challenge, which indicates management of HSPA12B expression could serve as a potential therapeutic target for ALI during sepsis/septic shock.
Title: HSPA12B attenuates acute lung injury during endotoxemia in mice.
HSPA12B plays a protective role in vascular endothelial barrier dysfunction by preserving the endothelial permeability during sepsis.
Title: Heat shock protein A12B protects against sepsis-induced impairment in vascular endothelial permeability.
Results suggest that miR-134 might influence neuronal cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by negatively modulating HSPA12B protein expression in a posttranscriptional manner
Title: Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B.
Results show that downregulation of miR-134 could induce neuroprotection against ischemic injury by upregulation of HSPA12B protein expression in vivo and in vitro models
Title: Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B.
Plasma extracellular HSPA12B is elevated in both septic mice and patients.
Title: Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

Go to the top of the page Help

Preferred Names: heat shock 70 kDa protein 12B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028306.3 → NP_082582.1 heat shock 70 kDa protein 12B

See identical proteins and their annotated locations for NP_082582.1

Status: PROVISIONAL

Source sequence(s)

AL831736

Consensus CDS

CCDS16755.1

UniProtKB/Swiss-Prot

Q9CZJ2

Related

ENSMUSP00000096950.4, ENSMUST00000099349.10

Conserved Domains (1) summary

cl17037
Location:61 → 529

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

130969332..130987905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239793.3 → XP_011238095.1 heat shock 70 kDa protein 12B isoform X1

Conserved Domains (1) summary

cl17037
Location:1 → 335

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_006500245.5 → XP_006500308.1 heat shock 70 kDa protein 12B isoform X2

Conserved Domains (1) summary

cl17037
Location:1 → 271

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily