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    Rec114 REC114 meiotic recombination protein [ Mus musculus (house mouse) ]

    Gene ID: 73673, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rec114provided by MGI
    Official Full Name
    REC114 meiotic recombination proteinprovided by MGI
    Primary source
    MGI:MGI:1920923
    See related
    Ensembl:ENSMUSG00000074269 AllianceGenome:MGI:1920923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410076I21Rik; 4930527A11Rik
    Summary
    Predicted to act upstream of or within DNA recombination and meiotic cell cycle. Is expressed in inner cell mass; ovary; primary oocyte; and secondary oocyte. Orthologous to human REC114 (REC114 meiotic recombination protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 6.3), large intestine adult (RPKM 6.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rec114 in Genome Data Viewer
    Location:
    9 B; 9 31.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58560139..58729684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58652856..58822706, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene inhibitory synaptic factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6742 Neighboring gene predicted gene, 53528 Neighboring gene CD276 antigen Neighboring gene STARR-positive B cell enhancer ABC_E1387 Neighboring gene neuroplastin Neighboring gene predicted gene 20620 Neighboring gene STARR-seq mESC enhancer starr_24285 Neighboring gene predicted gene, 21183 Neighboring gene VISTA enhancer mm1997 Neighboring gene STARR-seq mESC enhancer starr_24288 Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Neighboring gene neogenin Neighboring gene STARR-seq mESC enhancer starr_24289 Neighboring gene STARR-seq mESC enhancer starr_24290 Neighboring gene STARR-seq mESC enhancer starr_24291

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nore A, et al. Nat Commun, 2022 Nov 17. PMID 36396648, Free PMC Article
    2. REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. Boekhout M, et al. Mol Cell, 2019 Jun 6. PMID 31003867, Free PMC Article
    3. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
    4. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436
    5. Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4. Kumar R, et al. Life Sci Alliance, 2018 Dec. PMID 30569039, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.
      Title: Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis.
    2. Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
      Title: Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation.
    3. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
      Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
    4. A crystal structure defines a pleckstrin homology (PH) domain in REC114 and its direct intermolecular contacts with ANKRD31. In vivo, ANKRD31 stabilizes REC114 association with the PAR and elsewhere. Our findings inform a model in which ANKRD31 is a scaffold anchoring REC114 and other factors to specific genomic locations, thereby regulating DSB formation.
      Title: REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in meiotic DNA double-strand break formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiotic recombination protein REC114

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028598.1 → NP_082874.1  meiotic recombination protein REC114

      See identical proteins and their annotated locations for NP_082874.1

      Status: VALIDATED

      Source sequence(s)
      AK010725, AV474073, BY715467
      Consensus CDS
      CCDS52814.1
      UniProtKB/Swiss-Prot
      Q9CWH4
      Related
      ENSMUSP00000096271.5, ENSMUST00000098674.6
      Conserved Domains (1) summary
      pfam15165
      Location:20 → 254
      REC114-like; Meiotic recombination protein REC114-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58560139..58729684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155335.1 → XP_036011228.1  meiotic recombination protein REC114 isoform X7

      Conserved Domains (1) summary
      pfam15165
      Location:1 → 195
      REC114-like; Meiotic recombination protein REC114-like

    2. XM_036155336.1 → XP_036011229.1  meiotic recombination protein REC114 isoform X7

      Conserved Domains (1) summary
      pfam15165
      Location:1 → 195
      REC114-like; Meiotic recombination protein REC114-like

    3. XM_036155333.1 → XP_036011226.1  meiotic recombination protein REC114 isoform X4

      Conserved Domains (1) summary
      pfam15165
      Location:20 → 264
      REC114-like; Meiotic recombination protein REC114-like

    4. XM_036155332.1 → XP_036011225.1  meiotic recombination protein REC114 isoform X3

      Conserved Domains (1) summary
      pfam15165
      Location:20 → 266
      REC114-like; Meiotic recombination protein REC114-like

    5. XM_011242822.2 → XP_011241124.1  meiotic recombination protein REC114 isoform X2

      Conserved Domains (1) summary
      pfam15165
      Location:20 → 266
      REC114-like; Meiotic recombination protein REC114-like

    6. XM_011242820.2 → XP_011241122.1  meiotic recombination protein REC114 isoform X1

      Conserved Domains (1) summary
      pfam15165
      Location:20 → 294
      REC114-like; Meiotic recombination protein REC114-like

    7. XM_036155334.1 → XP_036011227.1  meiotic recombination protein REC114 isoform X5

      Conserved Domains (1) summary
      pfam15165
      Location:17 → 228
      REC114-like; Meiotic recombination protein REC114-like

    8. XM_006511491.4 → XP_006511554.1  meiotic recombination protein REC114 isoform X6

      Conserved Domains (1) summary
      pfam15165
      Location:20 → 208
      REC114-like; Meiotic recombination protein REC114-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWH4.1 GenPept UniProtKB/Swiss-Prot:Q9CWH4

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